SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2

Stable Identifier
R-HSA-5691108
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex containing the F-box/LRR-repeat protein 5 (FBXL5) protein (SKP1:FBXL5:CUL1:NEDD8) targets iron-responsive element-binding protein 2 (IREB2) for proteasomal degradation in iron-replete cells (Vashisht et al. 2009, Salahudeen et al. 2009). Cullin-1 (CUL1) is in neddylated form (NEDD8) which allows it to associate with this complex.
Literature References
PubMed ID Title Journal Year
19762596 Control of iron homeostasis by an iron-regulated ubiquitin ligase

Leibold, EA, Sun, D, Sangfelt, O, Bhaskaran, N, Powers, DN, Huang, X, Wohlschlegel, JA, Spruck, C, Durazo, A, Vashisht, AA, Zumbrennen, KB, Uhlén, M, Persson, A

Science 2009
19762597 An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

Ma, HW, Salahudeen, AA, Kinch, LN, Ruiz, JC, Li, Q, Grishin, NV, Bruick, RK, Thompson, JW

Science 2009
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of SKP1:FBXL5:CUL1:NEDD8 [cytosol]

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