Reactome | TFR2 [plasma membrane]

TFR2 [plasma membrane]

Stable Identifier

R-HSA-5691118

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transferrin receptor protein 2, TFR2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UP52 TFR2

Gene Names

TFR2

Chain

chain:1-801

Reference Genes

BioGPS Gene:7036 TFR2

COSMIC (genes):TFR2 TFR2

CTD Gene:7036 TFR2

dbSNP Gene:7036 TFR2

ENSEMBL:ENSG00000106327 TFR2

HGNC:11762 TFR2

KEGG Gene (Homo sapiens):7036 TFR2

Monarch:7036 TFR2

NCBI Gene:7036 TFR2

OMIM:604720 TFR2

UCSC:Q9UP52 TFR2

Reference Transcript

Other Identifiers

0001990092

11728023_a_at

17060677

207883_PM_s_at

207883_s_at

210215_PM_at

210215_at

3064159

3064160

3064161

3064165

3064167

3064168

3064169

3064170

3064171

3064173

3064174

3064175

3064177

3064178

3064180

3064183

3064184

3064186

3064189

3064190

3064191

3064192

3064193

3064194

3064195

3064196

3064199

40311_at

7036

8141560

A_23_P122896

GE80363

GE88085

GO:0003674

GO:0004998

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005887

GO:0006810

GO:0006826

GO:0006879

GO:0006898

GO:0006950

GO:0006953

GO:0007267

GO:0008150

GO:0009058

GO:0009897

GO:0010039

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0031410

GO:0032991

GO:0033572

GO:0034641

GO:0039706

GO:0042592

GO:0043226

GO:0045807

GO:0045944

GO:0051604

GO:0055072

GO:0071281

GO:0090277

GO:0140298

GO:1903319

GO:1990712

HMNXSV003057937

ILMN_1724738

PH_hs_0003982

TC07001674.hg

g4507454_3p_a_at

g5596369_3p_at

Participates

as a component of

TFR2 dimer:2xholoTF [plasma membrane] (Homo sapiens)

as an input of

TFR2 dimer binds 2xholoTF (Homo sapiens)

Inferred To

Homologues of TFR2 [plasma membrane] (Saccharomyces cerevisiae)

Tfr2 [plasma membrane] (Mus musculus)

Tfr2 [plasma membrane] (Rattus norvegicus)

TRE2 [plasma membrane] (Saccharomyces cerevisiae)

TFR2 [plasma membrane] (Bos taurus)

TFR2 [plasma membrane] (Canis familiaris)

TFR2 [plasma membrane] (Schizosaccharomyces pombe)

TFR2 [plasma membrane] (Sus scrofa)

VPS70 [plasma membrane] (Saccharomyces cerevisiae)

tfr2 [plasma membrane] (Danio rerio)

tfr2 [plasma membrane] (Xenopus tropicalis)

TRE1 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_016868062.1, NP_001193784.1, NP_003218.2, XP_005250610.1

OpenTargets

ENSG00000106327

HPA

ENSG00000106327-TFR2

GeneCards

Q9UP52

Ensembl

ENSG00000106327, ENSP00000223051, ENSP00000420525, ENST00000223051, ENST00000462107

PRO

Q9UP52

Pharos - Targets

Q9UP52

Orphanet

15605

HMDB Protein

HMDBP02336

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6UX06 OLFM4	3	OLFM4 [specific granule lumen] (R-HSA-6799634) OLFM4 [extracellular region] (R-HSA-6799672) OLFM4 [tertiary granule lumen] (R-HSA-6800893)	0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3