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HFE [plasma membrane]
Stable Identifier
R-HSA-5691126
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Hereditary hemochromatosis protein precursor, HFE_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
HFE binds TFRC dimer (Homo sapiens)
HFE [plasma membrane] (Homo sapiens)
HFE:TFRC dimer [plasma membrane] (Homo sapiens)
HFE [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q30201 HFE
Gene Names
HFE, HLAH
Chain
signal peptide:1-22, chain:23-348
Reference Genes
BioGPS Gene:3077 HFE
COSMIC (genes):HFE HFE
CTD Gene:3077 HFE
dbSNP Gene:3077 HFE
ENSEMBL:ENSG00000010704 HFE
HGNC:4886 HFE
KEGG Gene (Homo sapiens):3077 HFE
Monarch:3077 HFE
NCBI Gene:3077 HFE
OMIM:613609 HFE
UCSC:Q30201 HFE
Reference Transcript
RefSeq:NM_001300749.1 HFE
RefSeq:NM_139007.2 HFE
RefSeq:NM_139011.2 HFE
RefSeq:NM_139003.2 HFE
RefSeq:NM_139008.2 HFE
RefSeq:NM_139004.2 HFE
RefSeq:NM_139009.2 HFE
RefSeq:NM_000410.3 HFE
RefSeq:NM_139006.2 HFE
RefSeq:NM_139010.2 HFE
Other Identifiers
0000060500
0000630095
11736346_a_at
11736347_x_at
11736348_a_at
11741480_x_at
11742265_a_at
11751543_x_at
11753161_a_at
11759416_x_at
11763027_x_at
1553402_a_at
17005542
206086_3p_x_at
206086_x_at
206087_x_at
210864_x_at
211326_3p_x_at
211326_x_at
211327_x_at
211329_x_at
211330_s_at
211331_x_at
211332_x_at
211863_3p_x_at
211863_x_at
211866_3p_x_at
211866_x_at
214647_s_at
235754_at
2899113
2899114
2899116
2899117
2899118
2899119
2899120
2899121
2899126
2899127
2899128
2899129
2899131
2899132
2899133
2899134
2899135
2899136
2899137
2899138
2899139
2899140
2899141
2899142
2899143
3077
38913_at
50508_at
50664_at
80609_at
8117343
A_14_P116363
A_23_P145204
A_23_P342009
A_24_P103448
A_24_P111996
A_24_P289648
A_24_P354748
GE497653
GE59270
GO:0000003
GO:0002376
GO:0002626
GO:0002725
GO:0003674
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005856
GO:0005886
GO:0005887
GO:0006464
GO:0006810
GO:0006811
GO:0006879
GO:0006950
GO:0006953
GO:0007155
GO:0007165
GO:0007267
GO:0007565
GO:0008150
GO:0009056
GO:0009058
GO:0009897
GO:0010039
GO:0010106
GO:0010628
GO:0010862
GO:0015031
GO:0016020
GO:0016021
GO:0016192
GO:0022607
GO:0030509
GO:0030881
GO:0031410
GO:0032092
GO:0032435
GO:0032991
GO:0033572
GO:0034756
GO:0039706
GO:0042446
GO:0042592
GO:0043226
GO:0045177
GO:0045178
GO:0048260
GO:0048471
GO:0048856
GO:0055037
GO:0055072
GO:0055085
GO:0060586
GO:0065003
GO:0071281
GO:0090277
GO:0097421
GO:0098711
GO:1900121
GO:1900122
GO:1904283
GO:1904434
GO:1904437
GO:1990357
GO:1990459
GO:1990641
GO:1990712
GO:2000008
GO:2000059
GO:2000272
GO:2000273
GO:2001186
HMNXSV003019111
HMNXSV003024221
Hs.107216.0.A1_3p_at
Hs.20019.12.S2_3p_a_at
ILMN_1683345
ILMN_1743537
ILMN_2263236
ILMN_2302632
PH_hs_0023171
TC06000165.hg
TC06002643.hg
U60319_at
g11093523_3p_s_at
g11093523_3p_x_at
g11093525_3p_a_at
g11093525_3p_x_at
g11094314_3p_a_at
g11094320_3p_a_at
g11094320_3p_x_at
g11094322_3p_x_at
g11094324_3p_a_at
g11094326_3p_a_at
g11094326_3p_x_at
g11094328_3p_x_at
g3695108_3p_a_at
g3695110_3p_a_at
g4504376_3p_x_at
Participates
as a component of
HFE:TFRC dimer [plasma membrane] (Homo sapiens)
as an input of
HFE binds TFRC dimer (Homo sapiens)
Inferred To
MHCIA6 [plasma membrane]
(Gallus gallus)
si:dkey-52p2.5 [plasma membrane]
(Danio rerio)
MICA [plasma membrane]
(Gallus gallus)
Hfe [plasma membrane]
(Mus musculus)
Hfe [plasma membrane]
(Rattus norvegicus)
LOC100490728 [plasma membrane]
(Xenopus tropicalis)
XB5873923 [plasma membrane]
(Xenopus tropicalis)
YF5 [plasma membrane]
(Gallus gallus)
mhc1uka [plasma membrane]
(Danio rerio)
mhc1ula [plasma membrane]
(Danio rerio)
HFE [plasma membrane]
(Bos taurus)
HFE [plasma membrane]
(Canis familiaris)
HFE [plasma membrane]
(Danio rerio)
HFE [plasma membrane]
(Gallus gallus)
HFE [plasma membrane]
(Sus scrofa)
HFE [plasma membrane]
(Xenopus tropicalis)
LOC100495081 [plasma membrane]
(Xenopus tropicalis)
mhc1uma [plasma membrane]
(Danio rerio)
LOC103911752 [plasma membrane]
(Danio rerio)
mhc1lda [plasma membrane]
(Danio rerio)
LOC768350 [plasma membrane]
(Gallus gallus)
LOC107050833 [plasma membrane]
(Gallus gallus)
LOC108181672 [plasma membrane]
(Danio rerio)
mhc1lga [plasma membrane]
(Danio rerio)
LOC100859100 [plasma membrane]
(Gallus gallus)
mhc1lba [plasma membrane]
(Danio rerio)
mhc1lla [plasma membrane]
(Danio rerio)
mhc1laa [plasma membrane]
(Danio rerio)
mhc1lca [plasma membrane]
(Danio rerio)
mhc1lfa [plasma membrane]
(Danio rerio)
LOC417056 [plasma membrane]
(Gallus gallus)
mhc1zea [plasma membrane]
(Danio rerio)
mhc1lja [plasma membrane]
(Danio rerio)
mhc1zca [plasma membrane]
(Danio rerio)
mhc1uba [plasma membrane]
(Danio rerio)
mhc1zba [plasma membrane]
(Danio rerio)
mhc1zfa [plasma membrane]
(Danio rerio)
Homologues of HFE [plasma membrane]
(Danio rerio)
Homologues of HFE [plasma membrane]
(Gallus gallus)
Homologues of HFE [plasma membrane]
(Xenopus tropicalis)
cox16 [plasma membrane]
(Xenopus tropicalis)
BF1 [plasma membrane]
(Gallus gallus)
mhc100494167 [plasma membrane]
(Xenopus tropicalis)
mhc1zja [plasma membrane]
(Danio rerio)
BFIV21 [plasma membrane]
(Gallus gallus)
LOC107054704 [plasma membrane]
(Gallus gallus)
mhc1zaa [plasma membrane]
(Danio rerio)
mhc1b2 [plasma membrane]
(Xenopus tropicalis)
mr1-like [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_620575.1
,
NP_620580.1
,
NP_620576.1
,
NP_620577.1
,
NP_620578.1
,
NP_000401.1
,
NP_620579.1
,
NP_620572.1
,
NP_001287678.1
,
NP_620573.1
OpenTargets
ENSG00000010704
GeneCards
Q30201
HPA
ENSG00000010704-HFE
Ensembl
ENSP00000313776
,
ENSP00000315936
,
ENST00000357618
,
ENSP00000417404
,
ENSG00000010704
,
ENST00000397022
,
ENST00000353147
,
ENST00000461397
,
ENST00000349999
,
ENST00000488199
,
ENST00000336625
,
ENST00000317896
,
ENSP00000259699
,
ENST00000352392
,
ENSP00000420802
,
ENSP00000312342
,
ENSP00000420559
,
ENSP00000380217
,
ENSP00000337819
PRO
Q30201
Pharos - Targets
Q30201
Orphanet
16446
GlyGen
Q30201
HMDB Protein
HMDBP01659
PDB
1DE4
,
1A6Z
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61769 B2M
11
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [plasma membrane]
(R-HSA-167743)
0.656
4
UniProt:P02786 TFRC
5
TFRC(1-760) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869124)
TFRC(1-760) [Golgi membrane]
(R-HSA-434330)
TFRC(1-760) [cytoplasmic vesicle membrane]
(R-HSA-434196)
TFRC(1-760) [plasma membrane]
(R-HSA-917983)
TFRC(1-760) [endosome membrane]
(R-HSA-8961829)
0.621
3
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