Reactome | HFE [plasma membrane]

HFE [plasma membrane]

Stable Identifier

R-HSA-5691126

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Hereditary hemochromatosis protein precursor, HFE_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q30201 HFE

Gene Names

HFE, HLAH

Chain

signal peptide:1-22, chain:23-348

Reference Genes

BioGPS Gene:3077 HFE

COSMIC (genes):HFE HFE

CTD Gene:3077 HFE

dbSNP Gene:3077 HFE

ENSEMBL:ENSG00000010704 HFE

HGNC:4886 HFE

KEGG Gene (Homo sapiens):3077 HFE

Monarch:3077 HFE

NCBI Gene:3077 HFE

OMIM:613609 HFE

UCSC:Q30201 HFE

Reference Transcript

Other Identifiers

0000060500

0000630095

11736346_a_at

11736347_x_at

11736348_a_at

11741480_x_at

11742265_a_at

11751543_x_at

11753161_a_at

11759416_x_at

11763027_x_at

1553402_a_at

17005542

206086_3p_x_at

206086_x_at

206087_x_at

210864_x_at

211326_3p_x_at

211326_x_at

211327_x_at

211328_x_at

211329_x_at

211330_s_at

211331_x_at

211332_x_at

211863_3p_x_at

211863_x_at

211866_3p_x_at

211866_x_at

214647_s_at

235754_at

2899113

2899114

2899116

2899117

2899118

2899119

2899120

2899121

2899126

2899127

2899128

2899129

2899131

2899132

2899133

2899134

2899135

2899136

2899137

2899138

2899139

2899140

2899141

2899142

2899143

3077

38913_at

50508_at

50664_at

80609_at

8117343

A_14_P116363

A_23_P145204

A_23_P342009

A_24_P103448

A_24_P111996

A_24_P289648

A_24_P354748

GE497653

GE59270

GO:0000003

GO:0002376

GO:0002626

GO:0002725

GO:0003674

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005856

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0006811

GO:0006879

GO:0006950

GO:0006953

GO:0007155

GO:0007165

GO:0007267

GO:0007565

GO:0008150

GO:0009056

GO:0009058

GO:0009897

GO:0010039

GO:0010106

GO:0010628

GO:0010862

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0022607

GO:0030509

GO:0030881

GO:0031410

GO:0032092

GO:0032435

GO:0032991

GO:0033572

GO:0034641

GO:0034756

GO:0039706

GO:0042446

GO:0042592

GO:0043226

GO:0045177

GO:0045178

GO:0048260

GO:0048471

GO:0048856

GO:0055037

GO:0055072

GO:0055085

GO:0060586

GO:0065003

GO:0071281

GO:0090277

GO:0097421

GO:0098711

GO:1900121

GO:1900122

GO:1904283

GO:1904434

GO:1904437

GO:1990357

GO:1990459

GO:1990641

GO:1990712

GO:2000008

GO:2000059

GO:2000272

GO:2000273

GO:2001186

Hs.107216.0.A1_3p_at

Hs.20019.12.S2_3p_a_at

ILMN_1683345

ILMN_1743537

ILMN_2263236

ILMN_2302632

PH_hs_0023171

TC06000165.hg

TC06002643.hg

U60319_at

g11093523_3p_s_at

g11093523_3p_x_at

g11093525_3p_a_at

g11093525_3p_x_at

g11094314_3p_a_at

g11094320_3p_a_at

g11094320_3p_x_at

g11094322_3p_x_at

g11094324_3p_a_at

g11094326_3p_a_at

g11094326_3p_x_at

g11094328_3p_x_at

g3695108_3p_a_at

g3695110_3p_a_at

g4504376_3p_x_at

Participant Of

hasComponent

HFE:TFRC dimer [plasma membrane]

input

HFE binds TFRC dimer

Inferred To

XB5894692 [provisional:azgp1] [plasma membrane] (Xenopus tropicalis)

smg6 [plasma membrane] (Xenopus tropicalis)

si:dkey-52p2.5 [plasma membrane] (Danio rerio)

MICA [plasma membrane] (Gallus gallus)

Hfe [plasma membrane] (Mus musculus)

Hfe [plasma membrane] (Rattus norvegicus)

si:dkey-225f5.5 [plasma membrane] (Danio rerio)

YF5 [plasma membrane] (Gallus gallus)

ppp2r5b [plasma membrane] (Xenopus tropicalis)

mhc1uka [plasma membrane] (Danio rerio)

mhc1a [plasma membrane] (Xenopus tropicalis)

mhc1ula [plasma membrane] (Danio rerio)

HFE [plasma membrane] (Bos taurus)

HFE [plasma membrane] (Canis familiaris)

HFE [plasma membrane] (Danio rerio)

HFE [plasma membrane] (Gallus gallus)

HFE [plasma membrane] (Sus scrofa)

HFE [plasma membrane] (Xenopus tropicalis)

mhc1uma [plasma membrane] (Danio rerio)

LOC103911752 [plasma membrane] (Danio rerio)

mhc1lda [plasma membrane] (Danio rerio)

LOC108181672 [plasma membrane] (Danio rerio)

rtf1 [plasma membrane] (Xenopus tropicalis)

mhc1lga [plasma membrane] (Danio rerio)

mhc1lba [plasma membrane] (Danio rerio)

mhc1lla [plasma membrane] (Danio rerio)

mhc1laa [plasma membrane] (Danio rerio)

dcaf6 [plasma membrane] (Xenopus tropicalis)

mhc1lfa [plasma membrane] (Danio rerio)

mhc1zea [plasma membrane] (Danio rerio)

mhc1lja [plasma membrane] (Danio rerio)

plcb4 [plasma membrane] (Xenopus tropicalis)

mhc1zca [plasma membrane] (Danio rerio)

mhc1uba [plasma membrane] (Danio rerio)

mhc1zba [plasma membrane] (Danio rerio)

mhc1zfa [plasma membrane] (Danio rerio)

Homologues of HFE [plasma membrane] (Danio rerio)

Homologues of HFE [plasma membrane] (Gallus gallus)

Homologues of HFE [plasma membrane] (Xenopus tropicalis)

cox16 [plasma membrane] (Xenopus tropicalis)

BF1 [plasma membrane] (Gallus gallus)

mhc1zja [plasma membrane] (Danio rerio)

BFIV21 [plasma membrane] (Gallus gallus)

XB5820455 [provisional:mr1] [plasma membrane] (Xenopus tropicalis)

mhc1zaa [plasma membrane] (Danio rerio)

pacs2 [plasma membrane] (Xenopus tropicalis)

mr1-like [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001287678.1, NP_620573.1, NP_620575.1, NP_620580.1, NP_620576.1, NP_620577.1, NP_620578.1, NP_620579.1, NP_000401.1, NP_620572.1

OpenTargets

ENSG00000010704

GeneCards

Q30201

HPA

ENSG00000010704-HFE

Ensembl

ENSP00000420559, ENSP00000417404, ENSP00000337819, ENST00000397022, ENST00000357618, ENSP00000315936, ENST00000317896, ENSP00000259699, ENST00000461397, ENSP00000313776, ENST00000336625, ENST00000353147, ENSG00000010704, ENST00000488199, ENST00000349999, ENSP00000380217, ENST00000352392, ENSP00000420802, ENSP00000312342

PRO

Q30201

Orphanet

16446

HMDB Protein

HMDBP01659

PDB

1C42, 1DE4, 1A6Z

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.656	4
UniProt:P02786 TFRC	5	TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [plasma membrane] (R-HSA-917983)	0.621	3

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