CANDI binds CUL1

Stable Identifier
R-HSA-5691131
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cullin-associated NEDD8-dissociated protein 1 (CANDI, TIP120) is a key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, acting as a F-box protein exchange factor. CANDI binds cullin-1 (CUL1), preventing its association with SKP1 thereby disrupting the formation of SCF complexes. Neddylated CUL1 prevents CANDI binding (Zheng et al. 2002, Goldenberg et al. 2004).

Literature References
PubMed ID Title Journal Year
12504026 CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

Zheng, J, Yang, X, Harrell, JM, Ryzhikov, S, Shim, EH, Lykke-Andersen, K, Wei, N, Sun, H, Kobayashi, R, Zhang, H

Mol. Cell 2002
15537541 Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

Goldenberg, SJ, Cascio, TC, Shumway, SD, Garbutt, KC, Liu, J, Xiong, Y, Zheng, N

Cell 2004
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