Reactome | GLRX3 [cytosol]

GLRX3 [cytosol]

Stable Identifier

R-HSA-5691202

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Glutaredoxin-3, GLRX3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q13422 IKZF1

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External Reference Information

External Reference

UniProt:O76003 GLRX3

Gene Names

GLRX3, PICOT, TXNL2, HUSSY-22

Chain

initiator methionine:, chain:2-335

Reference Genes

BioGPS Gene:10539 GLRX3

COSMIC (genes):GLRX3 GLRX3

CTD Gene:10539 GLRX3

dbSNP Gene:10539 GLRX3

ENSEMBL:ENSG00000108010 GLRX3

ENSEMBL_homo_sapiens_GENE:ENSG00000108010.12 GLRX3

HGNC:15987 GLRX3

KEGG Gene (Homo sapiens):10539 GLRX3

Monarch:10539 GLRX3

NCBI Gene:10539 GLRX3

OMIM:612754 GLRX3

UCSC:O76003 GLRX3

Reference Transcript

Other Identifiers

10539

11716976_x_at

11757084_s_at

11758763_at

16710635

207506_PM_at

207506_at

209080_PM_x_at

209080_x_at

214205_PM_x_at

214205_x_at

230095_PM_at

230095_at

2892727

2892728

3271051

3271052

3271054

3271060

3271061

3271062

3271064

3271065

3271068

3271069

3271072

3271073

3271079

3271080

3271081

3271082

3271083

3271084

3271085

3271086

3271087

3271249

3271250

34807_at

48454_at

7931393

A_14_P120107

A_19_P00805607

A_24_P381029

GE55194

GO:0002026

GO:0003012

GO:0003013

GO:0003723

GO:0005080

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005938

GO:0006790

GO:0006879

GO:0010614

GO:0016226

GO:0030018

GO:0030425

GO:0042802

GO:0043226

GO:0044571

GO:0045454

GO:0046872

GO:0051536

GO:0051604

GO:0055065

GO:0097428

GO:1990229

HMNXSV003050038

Hs.20998.0.A1_3p_at

Hs.302081.0.S1_3p_s_at

ILMN_1758084

ILMN_2056479

PH_hs_0003122

TC10000933.hg

g5730103_3p_at

This entity regulates

Negatively

ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)

Cross References

RefSeq

NP_001186797.1, NP_006532.2

OpenTargets

ENSG00000108010

GeneCards

O76003

HPA

ENSG00000108010-GLRX3

Ensembl

ENSP00000330836, ENST00000331244, ENST00000481034, ENSP00000435445, ENSG00000108010, ENSP00000357633, ENST00000368644

PRO

O76003

Pharos - Targets

O76003

PDB

2DIY, 2WZ9, 2YAN, 3ZYW

Interactors (107)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6FI81 CIAPIN1	1	CIAPIN1 [cytosol] (R-HSA-2564765)	0.957	24
UniProt:Q9Y3E2 BOLA1			0.871	16
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.87	9
UniProt:O76081 RGS20	1	RGS20 [plasma membrane] (R-HSA-921136)	0.806	7
UniProt:Q9BQ66 KR412			0.781	7
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.781	7
UniProt:Q6UVY6 MOXD1			0.781	7
UniProt:Q16790 CA9	1	CA9 [plasma membrane] (R-HSA-1235065)	0.735	9
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.718	8
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.718	8
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.718	8
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.718	6
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.718	8
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.718	8
UniProt:Q9NQ86 TRIM36	1	TRIM36 [cytosol] (R-HSA-976029)	0.718	6
UniProt:O60336 MABP1			0.718	6
UniProt:Q5TA82 LCE2D	1	LCE2D [cytosol] (R-HSA-6814300)	0.718	6
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.704	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.696	5
UniProt:Q86YD3 TMM25			0.666	4
UniProt:O15162 PLS1			0.666	4
UniProt:Q04759 PRKCQ	9	PRKCQ [photoreceptor disc membrane] (R-HSA-2648997) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ(1-354) [cytosol] (R-HSA-212526) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ [cytosol] (R-HSA-58216) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [plasma membrane] (R-HSA-202346) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152)	0.602	5
UniProt:P60412 KRTAP10-11	1	KRTAP10-11 [cytosol] (R-HSA-6810243)	0.601	4
UniProt:Q9H3K6 BOLA2	1	BOLA2 [cytosol] (R-HSA-8950552)	0.564	4
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.564	2
UniProt:Q6FI81-1 CIAPIN1			0.558	2
UniProt:Q9BT81 SOX7	1	SOX7 [nucleoplasm] (R-HSA-5627712)	0.556	3
UniProt:Q9P2K3-2 RCOR3			0.556	3
UniProt:Q9NWS6 F118A			0.556	3
UniProt:Q9BYR2 KRTAP4-5	1	KRTAP4-5 [cytosol] (R-HSA-6809950)	0.556	5
UniProt:Q6P9E2 Q6P9E2			0.556	3
UniProt:Q9BYR3 KRTAP4-4	1	KRTAP4-4 [cytosol] (R-HSA-6809966)	0.556	3
UniProt:Q9BYR0 KRTAP4-7	1	KRTAP4-7 [cytosol] (R-HSA-6809963)	0.556	3
UniProt:P27658 COL8A1	20	3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173246) GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173055) 3x4Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173183) 3x4Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173195) 3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173270) GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173122) COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172239) 3x4Hyp-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172948) 3x4Hyp-3Hyp-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172976) 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173143) 3x4Hyp-3Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173217) 5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173023) 3x4Hyp-3Hyp-COL8A1(28-?) [extracellular region] (R-HSA-2470362) GalHyl-COL8A1(?-744) [extracellular region] (R-HSA-2470331) 3x4Hyp-3Hyp-COL8A1(?-744) [extracellular region] (R-HSA-2470328) 3x4Hyp-3Hyp-GalHyl-COL8A1(?-744) [extracellular region] (R-HSA-2470329) 3x4Hyp-5Hyl-COL8A1(?-744) [extracellular region] (R-HSA-2470366) GalHyl-COL8A1(28-?) [extracellular region] (R-HSA-2470364) 5Hyl-COL8A1(?-744) [extracellular region] (R-HSA-2470333) COL8A1(?-744) [extracellular region] (R-HSA-2470355)	0.556	3
UniProt:O95988 TCL1B			0.556	5
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.556	3
UniProt:Q9UQR1 ZN148			0.556	3
UniProt:O76081-6 RGS20			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q99288 DET1			0.556	3
UniProt:Q8NCP5 ZBT44			0.556	3
UniProt:Q5T4B2 GT253			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.556	3
UniProt:Q3E793 BOL1			0.556	3
UniProt:P22301 IL10	1	IL10 [extracellular region] (R-HSA-447125)	0.556	3
UniProt:Q96PB7 NOE3			0.556	3
UniProt:Q86VK4-3 ZNF410			0.556	3
UniProt:O95793 STAU1			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q6L8G4 KRTAP5-11	1	KRTAP5-11 [cytosol] (R-HSA-6810303)	0.556	3
UniProt:O76015 KRT38	1	KRT38 [cytosol] (R-HSA-6809615)	0.556	3
IntAct:EBI-16436789 CCSB ORF ID			0.556	5
UniProt:Q6L8H1 KRTAP5-4	1	KRTAP5-4 [cytosol] (R-HSA-6810264)	0.556	3
UniProt:Q6L8H2 KRTAP5-3	1	KRTAP5-3 [cytosol] (R-HSA-6810259)	0.556	7
UniProt:Q9BYQ0 KRTAP9-8	1	KRTAP9-8 [cytosol] (R-HSA-6809953)	0.556	3
UniProt:Q53S33 BOLA3			0.556	5
UniProt:Q9BYQ3 KRTAP9-3	1	KRTAP9-3 [cytosol] (R-HSA-6809954)	0.556	3
IntAct:EBI-10190127 4215			0.556	3
UniProt:P82987 ADAMTSL3	3	ADAMTSL3 [endoplasmic reticulum lumen] (R-HSA-5173176) glc-fuc-ADAMTSL3 [endoplasmic reticulum lumen] (R-HSA-5173051) O-fuc-ADAMTSL3 [endoplasmic reticulum lumen] (R-HSA-5172969)	0.556	3
UniProt:P78412 IRX6			0.556	5
IntAct:EBI-10178716 140258			0.556	3
UniProt:P39724 BOL3			0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q8IWZ5 TRI42			0.556	6
UniProt:Q86Y33-5 CDC20B			0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:P53582 METAP1	1	METAP1 [cytosol] (R-HSA-2534097)	0.556	3
UniProt:Q8NEP7 KLDC9			0.556	5
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	3
UniProt:Q9ULM2 ZNF490	1	ZNF490 [nucleoplasm] (R-HSA-1247870)	0.556	3
UniProt:Q16851 UGP2	1	UGP2 [cytosol] (R-HSA-453128)	0.556	3
UniProt:P34130 NTF4	1	NTF4 [extracellular region] (R-HSA-167063)	0.556	3
UniProt:Q9UFW8 CGBP1			0.556	3
UniProt:Q92824 PCSK5	2	PCSK5(115-913) [Golgi lumen] (R-HSA-166558) PCSK5 [extracellular region] (R-HSA-6784682)	0.556	3
UniProt:Q15973 ZNF124	1	ZNF124 [nucleoplasm] (R-HSA-975017)	0.556	3
IntAct:EBI-10173330 386677			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.556	3
UniProt:Q96Q83 ALKBH3	1	ALKBH3 [nucleoplasm] (R-HSA-113682)	0.556	3
UniProt:Q9BX79-6 STRA6			0.556	3
UniProt:Q9BQS7-3 Q9BQS73			0.556	3
UniProt:Q9P2W3 GNG13	1	GNG13 [plasma membrane] (R-HSA-164346)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:Q6NX49 ZNF544	1	ZNF544 [nucleoplasm] (R-HSA-1973895)	0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q9BZL6 PRKD2	1	PRKD2 [cytosol] (R-HSA-58214)	0.547	2
UniProt:Q86UY6 NAA40			0.527	2
UniProt:A4D1S0 KLRG2			0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P23921 RRM1	1	RRM1 [cytosol] (R-HSA-73638)	0.527	2
UniProt:Q8NEP3 DAAF1			0.508	2
UniProt:Q8TD31-3 CCHCR1			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.488	2
UniProt:P15976-2 GATA1			0.488	2
UniProt:Q99750 MDFI			0.488	2
UniProt:Q96PX9 PLEKHG4B	1	PLEKHG4B [cytosol] (R-HSA-9714841)	0.488	2
UniProt:Q96IK5 GMCL1			0.488	2
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.488	2
UniProt:Q8N448 LNX2			0.488	2

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