Reactome | ISCA2 [mitochondrial matrix]

ISCA2 [mitochondrial matrix]

Stable Identifier

R-HSA-5691207

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Iron-sulfur cluster assembly 2 homolog, mitochondrial, ISCA2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86U28 ISCA2

Gene Names

ISCA2, HBLD1

Chain

transit peptide:1-8, chain:9-154

Reference Genes

BioGPS Gene:122961 ISCA2

COSMIC (genes):ISCA2 ISCA2

CTD Gene:122961 ISCA2

dbSNP Gene:122961 ISCA2

ENSEMBL:ENSG00000165898 ISCA2

ENSEMBL_homo_sapiens_GENE:ENSG00000165898.14 ISCA2

HGNC:19857 ISCA2

KEGG Gene (Homo sapiens):122961 ISCA2

Monarch:122961 ISCA2

NCBI Gene:122961 ISCA2

OMIM:615317 ISCA2

UCSC:Q86U28 ISCA2

Reference Transcript

Other Identifiers

11720636_s_at

122961

16786460

226007_PM_at

226007_at

3544143

3544145

3544147

3544149

3544150

3544152

3544154

53993_at

7975705

A_14_P109283

A_14_P129152

A_23_P151746

GE79724

GO:0005506

GO:0005515

GO:0005739

GO:0005759

GO:0006790

GO:0016226

GO:0042802

GO:0043226

GO:0046872

GO:0051536

GO:0051537

GO:0051539

GO:0051604

GO:0106035

HMNXSV003046250

Hs.291079.0.A1_3p_at

ILMN_2136635

TC14000458.hg

Participates

as a component of

ISCA1:ISCA2 [mitochondrial matrix] (Homo sapiens)

Inferred To

ISCA2 [mitochondrial matrix] (Bos taurus)

ISCA2 [mitochondrial matrix] (Caenorhabditis elegans)

ISCA2 [mitochondrial matrix] (Canis familiaris)

ISCA2 [mitochondrial matrix] (Dictyostelium discoideum)

ISCA2 [mitochondrial matrix] (Gallus gallus)

ISCA2 [mitochondrial matrix] (Mus musculus)

ISCA2 [mitochondrial matrix] (Plasmodium falciparum)

ISCA2 [mitochondrial matrix] (Saccharomyces cerevisiae)

ISCA2 [mitochondrial matrix] (Schizosaccharomyces pombe)

ISCA2 [mitochondrial matrix] (Sus scrofa)

Isca2 [mitochondrial matrix] (Rattus norvegicus)

Dmel\CG13623 [mitochondrial matrix] (Drosophila melanogaster)

Cross References

RefSeq

NP_919255.2, NP_001258936.1

OpenTargets

ENSG00000165898

HPA

ENSG00000165898-ISCA2

GeneCards

Q86U28

Ensembl

ENSP00000450523, ENSP00000452007, ENST00000556816, ENSG00000165898, ENST00000554924

PRO

Q86U28

Pharos - Targets

Q86U28

Orphanet

23794

HMDB Protein

HMDBP08676

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.718	6
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3

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