Reactome | MYSM1 deubiquitinates Histone H2A

MYSM1 deubiquitinates Histone H2A

Stable Identifier

R-HSA-5691381

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MYSM1 is required for full activation of several transcriptional events, including androgen receptor (AR)-regulated target genes in prostate cancer cells. It is part of a regulatory protein complex with the histone acetyltransferase EP300 (p300) and KAT2B (CBP-associated factor (p/CAF)), regulating transcriptional initiation and elongaion by coordinating histone acetylation, H2A deubiquitination and linker histone dissociation. MYSM1 preferentially deubiquitinates H2A in hyperacetylated nucleosomes (Zhu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17707232	A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation Puc, J, Rosenfeld, MG, Wang, J, Glass, CK, Tempst, P, Ohgi, KA, Zhou, W, Erdjument-Bromage, H, Zhu, P	Mol. Cell	2007