PSMD14 cleaves K63-linked ubiquitin

Stable Identifier
R-HSA-5691431
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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PSMD14 (RPN11, POH1) is a subunit of the proteasomal 19S lid complex that specifically cleaves Lysine-63-linked polyubiquitin chains (Yao & Cohen 2002, Butler et al. 2012).

Literature References
PubMed ID Title Journal Year
12353037 A cryptic protease couples deubiquitination and degradation by the proteasome

Yao, T, Cohen, RE

Nature 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of PSMD14 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created