AKR1A1 oxidises BaPtDHD to BaP-7,8-dione

Stable Identifier
R-HSA-5692232
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Polycyclic aromatic hydrocarbons (PAHs) are pro-carcinogens which require further metabolic activation to ellicit their harmful effects. Aldo-keto reductases (AKRs) such as alcohol dehydrogenase [NADP+] (AKR1A1) can catalyse the oxidation of proximate carcinogenic PAH trans-dihydrodiols to reactive and redox active PAH o-quinones. Redox-cycling of PAH o-quinones generate reactive oxygen species and subsequent oxidative DNA damage. The proximate PAH carcinogen benzo[a]pyrene-7,8-trans-dihydrodiol (BaPtDHD) is oxidised by AKR1A1 to yield BaP-7,8-catechol which is unstable and auto-oxidises to yield BaP-7,8-dione (Zhang et al. 2012).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldo-keto reductase (NADP) activity of AKR1A1 [cytosol]
Physical Entity
Activity
Orthologous Events