ALD3A1 oxidises 4HPCP to CXPA

Stable Identifier
R-HSA-5692283
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in cancer chemo-resistance by oxidising activated forms of oxazaphosphorine drugs such as 4-hydroperoxycyclophosphamide (4HPCP) to the inactive metabolite carboxy-phosphamide (CXPA) (Moreb et al. 2007, Parajuli et al. 2014).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldehyde dehydrogenase [NAD(P)+] activity of ALDH3A1 [cytosol]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created