ATP13A1 transports Mn2+ from cytosol to ER lumen

Stable Identifier
R-HSA-5692462
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Manganese-transporting ATPase 13A1 (ATP13A1) mediates the transport of manganese (Mn2+) into the endoplasmic reticulum. ATPase activity is required for cellular manganese homeostasis (Cohen et al. 2013).

Literature References
PubMed ID Title Journal Year
24392018 The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum

Cohen, Y, Megyeri, M, Chen, OC, Condomitti, G, Riezman, I, Loizides-Mangold, U, Abdul-Sada, A, Rimon, N, Riezman, H, Platt, FM, Futerman, AH, Schuldiner, M

PLoS ONE 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
manganese transmembrane transporter activity, phosphorylative mechanism of ATP13A1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created