ATP13A2 transports cations from cytosol to lysosomal lumen

Stable Identifier
R-HSA-5692480
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The probable cation-transporting ATPase 13A2 (ATP13A2) is thought to play a role in intracellular cation homeostasis and the maintenance of neuronal integrity (Ramonet et al. 2012). Defects in ATP13A2 can cause Kufor-Rakeb syndrome (KRS; MIM:606693), a juvenile-onset Levodopa-responsive parkinsonism (Lai et al. 2012).

Literature References
PubMed ID Title Journal Year
22186024 PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

Ramonet, D, Podhajska, A, Stafa, K, Sonnay, S, Trancikova, A, Tsika, E, Pletnikova, O, Troncoso, JC, Glauser, L, Moore, DJ

Hum. Mol. Genet. 2012
23196729 Early-onset autosomal-recessive parkinsonian-pyramidal syndrome

Lai, HJ, Lin, CH, Wu, RM

Acta Neurol Taiwan 2012
Participants
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Catalyst Activity
Title
ATPase-coupled cation transmembrane transporter activity of ATP13A2 [lysosomal lumen]
Physical Entity
Activity
Orthologous Events
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Created