Reactome: A Curated Pathway Database

ATP13A2 transports cations from cytosol to lysosomal lumen

Stable Identifier
R-HSA-5692480
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The probable cation-transporting ATPase 13A2 (ATP13A2) is thought to play a role in intracellular cation homeostasis and the maintenance of neuronal integrity (Ramonet et al. 2012). Defects in ATP13A2 can cause Kufor-Rakeb syndrome (KRS; MIM:606693), a juvenile-onset Levodopa-responsive parkinsonism (Lai et al. 2012).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cation-transporting ATPase activity of ATP13A2 [lysosomal lumen] ATP13A2 [lysosomal lumen] cation-transporting ATPase activity (0019829)
Orthologous Events