Reactome | ATP13A2 transports cations from cytosol to lysosomal lumen

ATP13A2 transports cations from cytosol to lysosomal lumen

Stable Identifier

R-HSA-5692480

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lysosomal lumen, lysosomal membrane

ReviewStatus

5/5

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ATP13A2 transports cations from cytosol to lysosomal lumen

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The probable cation-transporting ATPase 13A2 (ATP13A2) is thought to play a role in intracellular cation homeostasis and the maintenance of neuronal integrity (Ramonet et al. 2012). Defects in ATP13A2 can cause Kufor-Rakeb syndrome (KRS; MIM:606693), a juvenile-onset Levodopa-responsive parkinsonism (Lai et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23196729	Early-onset autosomal-recessive parkinsonian-pyramidal syndrome Wu, RM, Lin, CH, Lai, HJ	Acta Neurol Taiwan	2012
22186024	PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity Sonnay, S, Troncoso, JC, Tsika, E, Ramonet, D, Trancikova, A, Pletnikova, O, Stafa, K, Moore, DJ, Podhajska, A, Glauser, L	Hum. Mol. Genet.	2012