Reactome | SEPT7 [cytosol]

SEPT7 [cytosol]

Stable Identifier

R-HSA-5692671

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor 1-phosphatidyl-1D-myo-inositol%203,5-bisphosphate%20%5BChEBI:16851%5D

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External Reference Information

External Reference

UniProt:Q16181 SEPTIN7

Gene Names

SEPTIN7, CDC10, SEPT7

Chain

initiator methionine:, chain:2-437

Reference Genes

BioGPS Gene:989 SEPTIN7

CTD Gene:989 SEPTIN7

dbSNP Gene:989 SEPTIN7

ENSEMBL:ENSG00000122545 SEPT7

ENSEMBL_homo_sapiens_GENE:ENSG00000122545.22 SEPTIN7

HGNC:1717 SEPTIN7

KEGG Gene (Homo sapiens):989 SEPTIN7

Monarch:989 SEPTIN7

NCBI Gene:989 SEPTIN7

OMIM:603151 SEPTIN7

UCSC:Q16181 SEPTIN7

Reference Transcript

RefSeq:NM_001788.5 SEPTIN7

Other Identifiers

11736062_s_at

11736063_s_at

11741022_x_at

11745246_x_at

17124454

213151_PM_s_at

213151_s_at

217721_PM_at

217721_at

2728795

2741346

2997092

2997094

2997096

2997098

2997099

2997106

2997115

2997120

2997121

2997122

2997130

2997134

2997135

2997137

2997143

2997146

2997147

2997157

2997159

2997160

2997161

2997162

2997163

2997164

2997165

2997166

2997167

2997199

2997200

2997202

3032373

3049205

3181548

3181558

32175_at

3373105

43525_at

8132292

989

A_23_P8482

A_24_P291973

GE81069

GO:0000166

GO:0000775

GO:0000776

GO:0000910

GO:0001725

GO:0003824

GO:0003924

GO:0005198

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0005930

GO:0005940

GO:0007049

GO:0007283

GO:0015630

GO:0016324

GO:0016476

GO:0016787

GO:0022414

GO:0030154

GO:0030496

GO:0031105

GO:0031514

GO:0032153

GO:0032154

GO:0042802

GO:0042995

GO:0043226

GO:0044782

GO:0045296

GO:0048856

GO:0051301

GO:0060090

GO:0060271

GO:0061640

GO:0070062

GO:0097227

GO:0097730

GO:1902857

HMNXSV003018615

HMNXSV003023469

Hs.184326.0.S2_3p_at

Hs.184326.1.S1_3p_a_at

ILMN_1729019

PH_hs_0028319

PH_hs_0033108

S72008_at

Participates

as an input of

SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)

as a component of

SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)

Inferred To

SEPTIN7 [cytosol] (Bos taurus)

SEPTIN7 [cytosol] (Canis familiaris)

SEPTIN7 [cytosol] (Sus scrofa)

sept7a [cytosol] (Danio rerio)

unc-59 [cytosol] (Caenorhabditis elegans)

SEPT7 [cytosol] (Drosophila melanogaster)

SEPT7 [cytosol] (Gallus gallus)

SEPT7 [cytosol] (Mus musculus)

SEPT7 [cytosol] (Rattus norvegicus)

SEPT7 [cytosol] (Saccharomyces cerevisiae)

SEPT7 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001779.3

OpenTargets

ENSG00000122545

GeneCards

Q16181

HPA

ENSG00000122545-SEPTIN7

Ensembl

ENSG00000122545, ENSP00000516132, ENSP00000344868, ENST00000705486, ENST00000350320

PRO

Q16181

Pharos - Targets

Q16181

PDB

2QAG, 6N0B, 6N12, 3T5D, 3TW4, 7M6J, 6UQQ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15019-1 SEPTIN2			0.728	8
UniProt:Q14141 SEPT6			0.669	3
UniProt:Q8IYM1 SEP12			0.655	17
UniProt:Q16181 SEPTIN7	1	SEPT7 [cytosol] (R-HSA-5692671)	0.558	2
UniProt:Q9NVA2 SEP11			0.534	2
UniProt:P42208	1	SEPT2 [cytosol] (R-MMU-5626657)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7
UniProt:Q9UHD8 SEPT9			0.482	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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