CDC14A,B bind MAPK6

Stable Identifier
R-HSA-5692749
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDC14A,B bind MAPK6
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphatases CDC14A and CDC14B bind directly to MAPK6 as assessed by yeast two hybrid and by co-immunoprecipitation (Tanguay et al, 2010; Hansen et al, 2008). CDC14 phosphatases are able to reverse the CDK1-dependent phosphorylation of MAPK6 in vitro, and overexpression of WT but not catalytically inactive forms of CDC14A or B in vivo leads to dephosphorylation of T698 (Hansen et al, 2008; Tanguay et al, 2010). These results suggest that CDC14 phosphatases reverse the CDK1-dependent phosphorylation of MAPK6 during mitosis. These reactions are depicted as occuring in the nucleoplasm, but the site of action has not been determined, and CDC14 and MAPK6 colocalize throughout the cell (Hansen et al, 2008).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
CDC14A,B bind MAPK6 (Bos taurus)
CDC14A,B bind MAPK6 (Canis familiaris)
CDC14A,B bind MAPK6 (Danio rerio)
CDC14A,B bind MAPK6 (Gallus gallus)
CDC14A,B bind MAPK6 (Mus musculus)
CDC14A,B bind MAPK6 (Rattus norvegicus)
CDC14A,B bind MAPK6 (Sus scrofa)
CDC14A,B bind MAPK6 (Xenopus tropicalis)
Authored
Meloche, S  (2015-05-12)
Reviewed
Meloche, S  (2015-05-12)
Mathien, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-05-13)