MAPK6 expression is stimulated in response to cytokines through JUN-mediated transcriptional activation. Phosphorylated JUN binds to a canonical JUN-binding site in the MAPK6 gene as assessed by ChIP, and stimulates transcription in response to TNFalpha (Wang et al, 2014).
Wang, W, Bian, K, Vallabhaneni, S, Zhang, B, Wu, RC, O'Malley, BW, Long, W
© 2019 Reactome