JUN binds MAPK6 gene

Stable Identifier
R-HSA-5692761
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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JUN binds MAPK6 gene
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MAPK6 expression is stimulated in response to cytokines through JUN-mediated transcriptional activation. Phosphorylated JUN binds to a canonical JUN-binding site in the MAPK6 gene as assessed by ChIP, and stimulates transcription in response to TNFalpha (Wang et al, 2014).

Literature References
PubMed ID Title Journal Year
24585635 ERK3 promotes endothelial cell functions by upregulating SRC-3/SP1-mediated VEGFR2 expression

Wang, W, Bian, K, Vallabhaneni, S, Zhang, B, Wu, RC, O'Malley, BW, Long, W

J. Cell. Physiol. 2014
Participants
Input
Output
Participant Of
hasEvent
Authored
Meloche, S  (2015-05-12)
Reviewed
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-05-13)