p-S182 MAPKAPK5 phosphorylates FOXO1

Stable Identifier
R-HSA-5692779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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p-S182 MAPKAPK5 phosphorylates FOXO1
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MAPKAPK5 phosphorylates FOXO1 at S215. This phosphorylation is essential for the FOXO1-dependent activation of RAG gene transcription during B-cell development and promotes the direct binding of FOXO1 to the RAG gene promoter (Chow et al, 2013).

Literature References
PubMed ID Title Journal Year
23878308 MK5 activates Rag transcription via Foxo1 in developing B cells

Chow, KT, Timblin, GA, McWhirter, SM, Schlissel, MS

J. Exp. Med. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T182-MAPKAPK5 [nucleoplasm]
Physical Entity
p-T182-MAPKAPK5 [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
p-S182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Canis familiaris)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Rattus norvegicus)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Xenopus tropicalis)
Authored
Meloche, S  (2015-05-12)
Reviewed
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-05-13)