Reactome | p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN

p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN

Stable Identifier

R-HSA-5692781

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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MAPK6 and MAPKAPK5 bind to the GDP-exchange factor KALRN, also known as Kalirin-7 or KAL7 (Brand et al, 2012). CaMKII-dependent phosphorylation of KALRN7 results in activation of PAK kinases in dendritic spines, potentially establishing a positive feedback loop that governs the MAPK6:MAPKAPK5 module in neuronal developement (Penzes et al, 2003; Xie et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
12546821	Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin Penzes, P, Beeser, A, Chernoff, J, Schiller, MR, Eipper, BA, Mains, RE, Huganir, RL	Neuron	2003
18031682	Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines Xie, Z, Srivastava, DP, Photowala, H, Kai, L, Cahill, ME, Woolfrey, KM, Shum, CY, Surmeier, DJ, Penzes, P	Neuron	2007
22508986	The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology Brand, F, Schumacher, S, Kant, S, Menon, MB, Simon, R, Turgeon, B, Britsch, S, Meloche, S, Gaestel, M, Kotlyarov, A	Mol. Cell. Biol.	2012