p-S215 FOXO1 positively regulates RAG gene expression

Stable Identifier
R-HSA-5692794
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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p-S215 FOXO1 positively regulates RAG gene expression
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Binding of p-S215 FOXO1 to the RAG genes promotes expression of RAG proteins, which are required for V(D)J recombination (Chow et al, 2013).

Literature References
PubMed ID Title Journal Year
23878308 MK5 activates Rag transcription via Foxo1 in developing B cells

Chow, KT, Timblin, GA, McWhirter, SM, Schlissel, MS

J. Exp. Med. 2013
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Authored
Meloche, S  (2015-05-12)
Reviewed
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-05-13)