Reactome | BACE1 [endosome membrane]

BACE1 [endosome membrane]

Stable Identifier

R-HSA-5692942

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN

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External Reference Information

External Reference

UniProt:P56817 BACE1

Gene Names

BACE1, BACE, KIAA1149

Chain

signal peptide:1-21, propeptide:22-45, chain:46-501

Reference Genes

BioGPS Gene:23621 BACE1

COSMIC (genes):BACE1 BACE1

CTD Gene:23621 BACE1

dbSNP Gene:23621 BACE1

ENSEMBL:ENSG00000186318 BACE1

HGNC:933 BACE1

KEGG:hsa:23621 BACE1

Monarch:23621 BACE1

NCBI Gene:23621 BACE1

OMIM:604252 BACE1

UCSC:P56817 BACE1

Reference Transcript

Participates

as an output of

BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)

Other forms of this molecule

BACE1(46-501) [plasma membrane]

BACE1(46-501) [Golgi-associated vesicle lumen]

7K-BACE1(46-501) [Golgi-associated vesicle lumen]

7K-BACE1 [Golgi-associated vesicle lumen]

BACE1(22-45) [Golgi-associated vesicle lumen]

7K-BACE1 [endoplasmic reticulum lumen]

BACE1 [endoplasmic reticulum lumen]

Cross References

Guide to Pharmacology - Targets

2330

ENSEMBL

ENSP00000318585, ENST00000510630, ENSP00000424536, ENSP00000403685, ENSG00000186318, ENSP00000402228, ENSP00000422461, ENST00000428381, ENST00000445823, ENST00000313005, ENST00000392937, ENST00000513780, ENSP00000475405

OpenTargets

ENSG00000186318

ZINC - FDA approved

BACE1_HUMAN

ZINC - Substances

BACE1_HUMAN

ZINC - Biogenic

BACE1_HUMAN

ZINC target

P56817

PRO

P56817

GlyGen

P56817

PDB

5QD3, 4I0E, 3INH, 3TPR, 6JT4, 2QU3, 3UQP, 4KE0, 4TRY, 4BFD, 4R92, 2OAH, 2XFK, 3UDK, 5T1U, 2WF4, 4JP9, 3IVH, 2NTR, 2ZJM, 5V0N, 2WJO, 5HTZ, 6UVY, 5I3W, 4L7H, 4B0Q, 2VKM, 3BRA, 4J0T, 4I0F, 5QCQ, 2QMG, 2QU2, 2VA5, 4KE1, 5T1W, 4J1F, 2PH8, 3UQR, 5YGX, 3UDM, 1XN3, 3IVI, 3RSV, 2ZJN, 2P83, 4XXS, 4JOO, 7B1Q, 3CIC, 4J0V, 6C2I, 6EJ3, 3DV5, 3OHF, 3R2F, 5I3V, 3KMX, 4I0G, 4D8C, 2VA6, 3OOZ, 5QD2, 4J1H, 5YGY, 2OHU, 3UDN, 4ACX, 6BFX, 4YBI, 5MXD, 7B1P, 3RSX, 4J17, 3DUY, 3CID, 4B70, 3OHH, 3KN0, 5QDC, 3IND, 4B05, 6EJ2, 2OHN, 1W51, 4AZY, 4J1I, 2PH6, 3SKF, 2VA7, 4R5N, 1XN2, 2OHT, 3L5D, 2Q15, 5MCO, 7MYU, 4J0Y, 5F00, 4L7J, 4N00, 4D88, 3TPJ, 3INE, 4I0H, 3KMY, 6OD6, 5QCT, 2P4J, 2QMF, 7D5A, 2WF0, 3UQU, 3L5E, 3IN3, 3VG1, 4DJU, 3ZMG, 4X2L, 2ZJH, 6FGY, 4J0Z, 3NSH, 5MCQ, 4RRN, 2ZJI, 3SKG, 4X7I, 4D89, 5F01, 4LXK, 3DV1, 5I3Y, 4J0P, 1PY1, 4K8S, 3INF, 5HD0, 5QD5, 4LXM, 5MBW, 1W50, 2ZHR, 3IN4, 3L5F, 3UDP, 6UVP, 3QBH, 1YM4, 6JSF, 3K5F, 4RRO, 7D2X, 4FSL, 4DJV, 3U6A, 6E3Z, 5QDB, 2OHR, 2OHM, 4B00, 7N66, 6NV7, 4IVS, 3ZOV, 7B1E, 3RVI, 6UWP, 3H0B, 7DCZ, 2WEZ, 3L38, 4GID, 3UDQ, 4I0I, 2QP8, 1YM2, 2ZDZ, 3K5G, 7D36, 4DJW, 4RRS, 4HZT, 5ENK, 3TPL, 4D83, 4RCE, 3UQW, 4IVT, 6UWV, 2IQG, 3MSJ, 5QCS, 2ZHS, 3IXJ, 3L5B, 5UYU, 2VJ6, 4DPI, 2VIE, 6NV9, 2OHS, 4GMI, 7D2V, 6BFE, 3WB4, 4DJX, 2VNM, 4D85, 3LHG, 6WNY, 5QDD, 5QCP, 4ZSM, 5DQC, 3L3A, 4ZPE, 2ZHT, 3IXK, 2QZL, 4DI2, 3MSK, 3BUF, 4FRS, 3L5C, 5QD4, 3UDR, 2ZE1, 6JSE, 4DH6, 4I0J, 5HE5, 2VNN, 4DJY, 6BFD, 3WB5, 2HIZ, 2G94, 5ENM, 4LXA, 3RTM, 4PZW, 5EZZ, 5QD1, 4H3G, 3HW1, 2OHL, 3MSL, 4B1C, 3LNK, 4FM7, 4FS4, 4R93, 6UVV, 2ZHU, 3FKT, 3R1G, 2VJ7, 4I0Z, 5HE4, 3K5C, 7MYR, 5QCX, 5HU1, 4RCF, 3RTN, 4PZX, 4H3I, 2OHQ, 4H3J, 6DHC, 1M4H, 4DVF, 4FM8, 3N4L, 2QK5, 2ZJJ, 5HDV, 4R95, 5QCV, 3CKP, 3S7L, 4TRZ, 4ZPF, 4RCD, 2VJ9, 3K5D, 4R8Y, 3CKR, 5KR8, 2IS0, 3RU1, 4B72, 5HU0, 5QD9, 4ZSP, 3UQX, 2HM1, 4I10, 3PI5, 3HVG, 4EXG, 3L58, 2VIY, 5QD7, 3EXO, 5HE7, 2ZHV, 2QZK, 7MYI, 4ZPG, 4HA5, 4DPF, 3VV6, 3KYR, 5QCW, 4ZSQ, 4B77, 3RTH, 5QCO, 3QI1, 4XKX, 4FRI, 4I11, 5QD0, 3BUG, 4ZSR, 1FKN, 3L59, 6JSN, 2VIZ, 3S7M, 4J1K, 2VIJ, 2WF1, 2F3F, 2Q11, 3LPI, 2XFI, 6DMI, 3VV7, 6NW3, 2FDP, 4DV9, 4K9H, 5QD8, 1UJJ, 4FRJ, 2B8L, 6PZ4, 6JSG, 4I1C, 4JPC, 4B78, 2OHK, 5CLM, 1TQF, 2IRZ, 5HDU, 3UDY, 2WF2, 4B1D, 4J1C, 2ZJK, 2OF0, 4LC7, 3LPJ, 4FSE, 4EWO, 5I3X, 5QCZ, 4H3F, 5IE1, 3DM6, 4FCO, 4WY1, 4FRK, 3UDJ, 4WY6, 7F1D, 5EZX, 4JPE, 3LPK, 3UDH, 3BUH, 4I12, 2XFJ, 3IGB, 4H1E, 5QCU, 4J1E, 6EQM, 3VF3, 5QDA, 4ACU, 4WTU, 3UFL, 2OHP, 6JT3, 3S2O, 4L7G, 5QCR, 1SGZ, 2P8H, 4I0D, 2WF3, 4TRW, 4B1E, 4R91, 5HDX, 2B8V, 2ZJL, 5HDZ, 5KQF, 5QD6, 2F3E, 3VEU, 4DUS, 6BFW, 4FGX, 3VV8, 2QMD, 4BEK, 3TPP, 5QCY, 1XS7, 3I25, 5TOL, 3CIB, 1UJK

ZINC - Investigational

BACE1_HUMAN

ZINC - Metabolites

BACE1_HUMAN

GeneCards

BACE1

HPA

ENSG00000186318-BACE1

Pharos - Targets

P56817

ZINC - Predictions - Purchasable

BACE1_HUMAN

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.865	11
UniProt:Q9UJY5 GGA1	2	GGA1 [endosome membrane] (R-HSA-5692930) GGA1 [early endosome membrane] (R-HSA-8854136)	0.668	4
UniProt:P49768 PSEN1	6	PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606)	0.639	6
UniProt:P10997 IAPP	2	IAPP(34-70) [extracellular region] (R-HSA-420076) IAPP(1-89) [cytosol] (R-HSA-186631)	0.558	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.556	4
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.544	2
UniProt:Q9UJY4 GGA2	2	GGA2 [early endosome membrane] (R-HSA-8854140) GGA2 [endosome membrane] (R-HSA-5692937)	0.544	2
UniProt:Q8BNX1	1	Clec4g [plasma membrane] (R-MMU-1472852)	0.524	2
UniProt:Q03721 KCNC4	1	KCNC4 [plasma membrane] (R-HSA-977458)	0.524	3
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [specific granule membrane] (R-HSA-6799566)	0.454	3

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