BACE1 [endosome membrane]

Stable Identifier
R-HSA-5692942
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN
BACE1 [endosome membrane] icon
External Reference Information
External Reference
Gene Names
BACE1, BACE, KIAA1149
Chain
signal peptide:1-21, propeptide:22-45, chain:46-501
Other Identifiers
0005360487
11716390_a_at
11716391_a_at
11749940_a_at
11753657_a_at
11753658_x_at
11754653_a_at
16744822
217904_s_at
222462_s_at
222463_s_at
224335_s_at
23621
3393256
3393258
3393259
3393260
3393261
3393262
3393263
3393264
3393265
3393267
3393268
3393270
3393273
3393276
3393277
3393279
3393280
3393281
3393282
3393284
3393295
3393296
3393297
3393298
44849_at
45790_at
7951910
A_33_P3240936
A_33_P3240941
GE58458
GO:0001540
GO:0003674
GO:0004175
GO:0004190
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005771
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005802
GO:0005886
GO:0005887
GO:0006508
GO:0006509
GO:0006810
GO:0007267
GO:0008021
GO:0008150
GO:0008219
GO:0008233
GO:0008798
GO:0009314
GO:0009986
GO:0010008
GO:0010288
GO:0016020
GO:0016021
GO:0016192
GO:0016787
GO:0019899
GO:0030424
GO:0030425
GO:0030659
GO:0031410
GO:0034641
GO:0042987
GO:0042995
GO:0043025
GO:0043226
GO:0043525
GO:0044267
GO:0045121
GO:0050435
GO:0050804
GO:0050877
GO:0050966
GO:0055037
GO:0060134
GO:0070931
GO:0071280
GO:0071287
GO:0098686
GO:1904646
GO:2000300
Hs.49349.0.S3_3p_a_at
ILMN_1797804
ILMN_2320349
PH_hs_0003439
TC11002335.hg
TC11003367.hg
TC11003368.hg
g13568406_3p_s_at
g6118538_3p_a_at
g6912265_3p_a_at
Participant Of
Other forms of this molecule
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
2OHR, 4LXK, 6DMI, 6JSN, 4ZPE, 3BUH, 2WF3, 2VJ7, 1FKN, 4B78, 4I12, 4HZT, 5HE7, 3S2O, 3VEU, 3DM6, 3OHH, 5MBW, 6UWP, 3UDY, 2ZJI, 4PZX, 2NTR, 3IXJ, 6NV9, 4BEK, 3RU1, 4FS4, 3VV7, 3KN0, 3CKP, 4TRZ, 4R92, 6UVP, 2PH6, 3INH, 4J1K, 4B1D, 4KE1, 2F3F, 4DJY, 3LPJ, 1PY1, 2QU2, 2VNM, 2OAH, 6JT4, 3I25, 3QI1, 5KR8, 6UVV, 3IN3, 4I10, 4TRW, 3BRA, 3UQR, 4ACX, 5HE4, 4I0G, 4DJV, 4DH6, 2ZJK, 4ZSQ, 4JPC, 4X7I, 3MSJ, 3CIB, 4FM8, 4FRK, 3VG1, 4RRO, 2OHT, 6JSF, 2ZE1, 2FDP, 3PI5, 5F01, 6E3Z, 4GMI, 3RSV, 4J1H, 4R8Y, 6EJ2, 4ZPG, 3L5C, 1XN2, 2QMF, 2IRZ, 3TPJ, 3K5F, 5YGY, 4I0I, 3UDJ, 3WB5, 4DVF, 4FSL, 2VIE, 3UQW, 2HIZ, 4R95, 3IND, 6C2I, 5HTZ, 2QP8, 3IVI, 2ZDZ, 2B8V, 2ZJM, 6JSG, 4I11, 4J0Z, 6EQM, 4WY1, 4D89, 4K8S, 6NV7, 1YM4, 4XKX, 3MSL, 3CID, 4B05, 2QZK, 2WF0, 4B70, 5TOL, 4ZSR, 2VA5, 4RCD, 5T1U, 4JPE, 1W50, 4IVS, 4X2L, 4LC7, 4RCF, 4H3I, 3L38, 4J0V, 5V0N, 2QK5, 3L5E, 2VKM, 3TPP, 4RRS, 4FRS, 2ZHS, 4ACU, 5ENK, 3UDM, 5CLM, 5HU1, 4DJX, 5HDV, 2G94, 6JT3, 3HVG, 3RTH, 3WB4, 3UDH, 3L58, 3K5D, 4EXG, 2VA7, 3DV1, 4I0Z, 4D85, 6PZ4, 1M4H, 3H0B, 4JP9, 3VF3, 4B77, 3CKR, 5MXD, 3BUG, 2WF2, 6JSE, 2WJO, 4RRN, 4J0P, 3OHF, 2OHN, 4FRJ, 5EZZ, 5HD0, 4FCO, 2ZHU, 5MCQ, 3SKG, 4GID, 3QBH, 1XS7, 4XXS, 3UDP, 3DV5, 3KMY, 3RTN, 3IGB, 4YBI, 4ZSP, 2P83, 2OHK, 2Q11, 3NSH, 3EXO, 5YGX, 4H3F, 3LPI, 2ZJH, 2OHQ, 2IQG, 3RVI, 4I0F, 5HDZ, 3UQP, 2XFK, 1UJK, 4J0Y, 2VJ6, 3VV6, 4FM7, 4R5N, 5F00, 5I3Y, 3U6A, 3UDR, 4AZY, 4J1F, 4J0T, 3IXK, 2WF4, 4RCE, 2PH8, 2VNN, 4DV9, 4L7J, 3LPK, 5HDU, 3ZOV, 6DHC, 2F3E, 3INF, 4B1C, 2OHM, 6BFX, 2VIY, 3UFL, 4I0D, 3S7L, 3RSX, 3UQU, 4L7G, 2VJ9, 3IN4, 2OHS, 1TQF, 4TRY, 4DJW, 5I3W, 4BFD, 4H1E, 3MSK, 4J1C, 4WTU, 2ZJJ, 4I1C, 2XFI, 4B00, 4DI2, 2QMG, 2OF0, 3S7M, 5IE1, 5MCO, 2ZHR, 3VV8, 6BFE, 2XFJ, 3TPL, 5KQF, 3R2F, 4B1E, 4DPI, 4D83, 2QU3, 3UDK, 6NW3, 3K5G, 2P4J, 4FSE, 3L5B, 5HDX, 4LXM, 2VIJ, 2B8L, 1SGZ, 3FKT, 6OD6, 4B0Q, 4JOO, 4I0E, 6UWV, 2OHU, 3N4L, 3IVH, 2ZJL, 4N00, 5EZX, 4WY6, 4FRI, 3LNK, 3OOZ, 4D8C, 2WEZ, 3L3A, 2ZHT, 3ZMG, 3CIC, 5I3X, 4J1E, 1YM2, 3HW1, 6UVY, 3TPR, 3DUY, 4ZSM, 4DUS, 3UDN, 1XN3, 5UYU, 4L7H, 3L5D, 2IS0, 6BFW, 4R93, 4HA5, 3K5C, 3LHG, 4H3G, 2QZL, 3L59, 4IVT, 5HU0, 5HE5, 3R1G, 5T1W, 2ZJN, 3BUF, 4PZW, 2WF1, 4D88, 1UJJ, 4I0H, 2VIZ, 4ZPF, 4J17, 2OHP, 4B72, 5ENM, 2VA6, 2ZHV, 4LXA, 5I3V, 3UDQ, 4K9H, 4DJU, 4H3J, 4J1I, 6BFD, 3SKF, 1W51, 6FGY, 3L5F, 4FGX, 2Q15, 4DPF, 2OHL, 2HM1, 3KYR, 6EJ3, 3RTM, 4EWO, 4KE0, 4R91, 5DQC, 2P8H, 4I0J, 3KMX, 3INE, 2QMD, 3UQX
ZINC - Investigational
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P05067 APP  20 0.797 8
 UniProt:Q9UJY5 GGA1  2 0.684 4
 UniProt:P49768 PSEN1  6 0.639 6
 UniProt:P10997 IAPP  2 0.558 2
 UniProt:Q9Y287 ITM2B  1 0.556 4
 UniProt:Q9UJY4 GGA2  2 0.544 2
 UniProt:Q9NZ52 GGA3  3 0.544 2
 UniProt:Q03721 KCNC4  1 0.524 3
 UniProt:Q8BNX1  1 0.524 2
 UniProt:O14672 ADAM10  6 0.508 3
 UniProt:Q9UNH7 SNX6      0.499 2
 UniProt:Q14254 FLOT2  1 0.499 2
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