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BACE1 [endosome membrane]
Stable Identifier
R-HSA-5692942
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9Y287 ITM2B
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) (Homo sapiens)
BACE1 [endosome membrane] (Homo sapiens)
BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)
BACE1 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56817 BACE1
Gene Names
BACE1, BACE, KIAA1149
Chain
signal peptide:1-21, propeptide:22-45, chain:46-501
Reference Genes
COSMIC (genes):BACE1 BACE1
dbSNP Gene:23621 BACE1
ENSEMBL:ENSG00000186318 BACE1
Participates
as an output of
BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)
Other forms of this molecule
BACE1 [endoplasmic reticulum lumen]
7K-BACE1 [endoplasmic reticulum lumen]
BACE1(22-45) [Golgi-associated vesicle lumen]
7K-BACE1 [Golgi-associated vesicle lumen]
7K-BACE1(46-501) [Golgi-associated vesicle lumen]
BACE1(46-501) [Golgi-associated vesicle lumen]
BACE1(46-501) [plasma membrane]
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.865
11
UniProt:Q9UJY5 GGA1
2
GGA1 [early endosome membrane]
(R-HSA-8854136)
GGA1 [endosome membrane]
(R-HSA-5692930)
0.668
4
UniProt:P49768 PSEN1
6
PSEN1(1-467) [plasma membrane]
(R-HSA-201606)
PSEN1(299-467) [azurophil granule membrane]
(R-HSA-6799234)
PSEN1(1-467) [azurophil granule membrane]
(R-HSA-6799235)
PSEN1(1-298) [azurophil granule membrane]
(R-HSA-6799209)
PSEN1(1-298) [plasma membrane]
(R-HSA-2534298)
PSEN1(299-467) [plasma membrane]
(R-HSA-2534245)
0.639
6
UniProt:P10997 IAPP
2
IAPP(34-70) [extracellular region]
(R-HSA-420076)
IAPP(1-89) [cytosol]
(R-HSA-186631)
0.558
2
UniProt:Q9Y287 ITM2B
1
ITM2B(244-266) [extracellular region]
(R-HSA-976878)
0.556
4
UniProt:Q9UJY4 GGA2
2
GGA2 [early endosome membrane]
(R-HSA-8854140)
GGA2 [endosome membrane]
(R-HSA-5692937)
0.544
2
UniProt:Q9NZ52 GGA3
3
GGA3 [endosome membrane]
(R-HSA-5692936)
GGA3 [early endosome membrane]
(R-HSA-8854137)
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
0.544
2
UniProt:Q03721 KCNC4
1
KCNC4 [plasma membrane]
(R-HSA-977458)
0.524
3
UniProt:Q8BNX1
1
Clec4g [plasma membrane]
(R-MMU-1472852)
0.524
2
UniProt:Q9UNH7 SNX6
0.499
2
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
0.454
3
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