NAT8,8B acetylate BACE1

Stable Identifier
R-HSA-5693001
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

N-acetyltransferase 8 and 8B (NAT8, 8B) can mediate the molecular stabilisation of BACE1, the membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer disease amyloid beta-peptide. Specifically, nascent BACE1 is transiently acetylated on seven lysine residues in the ER lumen which protects the nascent protein from degradation in the ER Golgi intermediate compartment (ERGIC) and allows it to reach the Golgi apparatus (Ko & Puglielli 2009, Costantini et al. 2007). Lysine-acetylated BACE1 (7K-BACE1) is deacetylated in the Golgi apparatus.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor of NAT8, 8B [endoplasmic reticulum membrane]
Physical Entity
Activity