7K-BACE1 [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-5693006
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN
Icon
7K-BACE1 [endoplasmic reticulum lumen] icon
7K-BACE1 [endoplasmic reticulum lumen] icon
Locations in the PathwayBrowser
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External Reference Information
External Reference
UniProt:P56817 BACE1
Gene Names
BACE1, BACE, KIAA1149
Chain
signal peptide:1-21, propeptide:22-45, chain:46-501
Reference Genes
BioGPS Gene:23621 BACE1
COSMIC (genes):BACE1 BACE1
CTD Gene:23621 BACE1
dbSNP Gene:23621 BACE1
ENSEMBL:ENSG00000186318 BACE1
HGNC:933 BACE1
KEGG:hsa:23621 BACE1
Monarch:23621 BACE1
NCBI Gene:23621 BACE1
OMIM:604252 BACE1
UCSC:P56817 BACE1
Reference Transcript
Participates
as an output of
as an input of
Other forms of this molecule
BACE1 [endosome membrane]
BACE1(46-501) [plasma membrane]
BACE1(46-501) [Golgi-associated vesicle lumen]
7K-BACE1(46-501) [Golgi-associated vesicle lumen]
7K-BACE1 [Golgi-associated vesicle lumen]
BACE1(22-45) [Golgi-associated vesicle lumen]
BACE1 [endoplasmic reticulum lumen]
Modified Residues
Name
N6-acetyl-L-lysine at 126
Coordinate
126
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 275
Coordinate
275
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 279
Coordinate
279
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 285
Coordinate
285
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 299
Coordinate
299
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 300
Coordinate
300
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 307
Coordinate
307
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
Guide to Pharmacology - Targets
ENSEMBL
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
5QD3, 4I0E, 3INH, 3TPR, 6JT4, 2QU3, 3UQP, 4KE0, 4TRY, 4BFD, 4R92, 2OAH, 2XFK, 3UDK, 5T1U, 2WF4, 4JP9, 3IVH, 2NTR, 2ZJM, 5V0N, 2WJO, 5HTZ, 6UVY, 5I3W, 4L7H, 4B0Q, 2VKM, 3BRA, 4J0T, 4I0F, 5QCQ, 2QMG, 2QU2, 2VA5, 4KE1, 5T1W, 4J1F, 2PH8, 3UQR, 5YGX, 3UDM, 1XN3, 3IVI, 3RSV, 2ZJN, 2P83, 4XXS, 4JOO, 7B1Q, 3CIC, 4J0V, 6C2I, 6EJ3, 3DV5, 3OHF, 3R2F, 5I3V, 3KMX, 4I0G, 4D8C, 2VA6, 3OOZ, 5QD2, 4J1H, 5YGY, 2OHU, 3UDN, 4ACX, 6BFX, 4YBI, 5MXD, 7B1P, 3RSX, 4J17, 3DUY, 3CID, 4B70, 3OHH, 3KN0, 5QDC, 3IND, 4B05, 6EJ2, 2OHN, 1W51, 4AZY, 4J1I, 2PH6, 3SKF, 2VA7, 4R5N, 1XN2, 2OHT, 3L5D, 2Q15, 5MCO, 7MYU, 4J0Y, 5F00, 4L7J, 4N00, 4D88, 3TPJ, 3INE, 4I0H, 3KMY, 6OD6, 5QCT, 2P4J, 2QMF, 7D5A, 2WF0, 3UQU, 3L5E, 3IN3, 3VG1, 4DJU, 3ZMG, 4X2L, 2ZJH, 6FGY, 4J0Z, 3NSH, 5MCQ, 4RRN, 2ZJI, 3SKG, 4X7I, 4D89, 5F01, 4LXK, 3DV1, 5I3Y, 4J0P, 1PY1, 4K8S, 3INF, 5HD0, 5QD5, 4LXM, 5MBW, 1W50, 2ZHR, 3IN4, 3L5F, 3UDP, 6UVP, 3QBH, 1YM4, 6JSF, 3K5F, 4RRO, 7D2X, 4FSL, 4DJV, 3U6A, 6E3Z, 5QDB, 2OHR, 2OHM, 4B00, 7N66, 6NV7, 4IVS, 3ZOV, 7B1E, 3RVI, 6UWP, 3H0B, 7DCZ, 2WEZ, 3L38, 4GID, 3UDQ, 4I0I, 2QP8, 1YM2, 2ZDZ, 3K5G, 7D36, 4DJW, 4RRS, 4HZT, 5ENK, 3TPL, 4D83, 4RCE, 3UQW, 4IVT, 6UWV, 2IQG, 3MSJ, 5QCS, 2ZHS, 3IXJ, 3L5B, 5UYU, 2VJ6, 4DPI, 2VIE, 6NV9, 2OHS, 4GMI, 7D2V, 6BFE, 3WB4, 4DJX, 2VNM, 4D85, 3LHG, 6WNY, 5QDD, 5QCP, 4ZSM, 5DQC, 3L3A, 4ZPE, 2ZHT, 3IXK, 2QZL, 4DI2, 3MSK, 3BUF, 4FRS, 3L5C, 5QD4, 3UDR, 2ZE1, 6JSE, 4DH6, 4I0J, 5HE5, 2VNN, 4DJY, 6BFD, 3WB5, 2HIZ, 2G94, 5ENM, 4LXA, 3RTM, 4PZW, 5EZZ, 5QD1, 4H3G, 3HW1, 2OHL, 3MSL, 4B1C, 3LNK, 4FM7, 4FS4, 4R93, 6UVV, 2ZHU, 3FKT, 3R1G, 2VJ7, 4I0Z, 5HE4, 3K5C, 7MYR, 5QCX, 5HU1, 4RCF, 3RTN, 4PZX, 4H3I, 2OHQ, 4H3J, 6DHC, 1M4H, 4DVF, 4FM8, 3N4L, 2QK5, 2ZJJ, 5HDV, 4R95, 5QCV, 3CKP, 3S7L, 4TRZ, 4ZPF, 4RCD, 2VJ9, 3K5D, 4R8Y, 3CKR, 5KR8, 2IS0, 3RU1, 4B72, 5HU0, 5QD9, 4ZSP, 3UQX, 2HM1, 4I10, 3PI5, 3HVG, 4EXG, 3L58, 2VIY, 5QD7, 3EXO, 5HE7, 2ZHV, 2QZK, 7MYI, 4ZPG, 4HA5, 4DPF, 3VV6, 3KYR, 5QCW, 4ZSQ, 4B77, 3RTH, 5QCO, 3QI1, 4XKX, 4FRI, 4I11, 5QD0, 3BUG, 4ZSR, 1FKN, 3L59, 6JSN, 2VIZ, 3S7M, 4J1K, 2VIJ, 2WF1, 2F3F, 2Q11, 3LPI, 2XFI, 6DMI, 3VV7, 6NW3, 2FDP, 4DV9, 4K9H, 5QD8, 1UJJ, 4FRJ, 2B8L, 6PZ4, 6JSG, 4I1C, 4JPC, 4B78, 2OHK, 5CLM, 1TQF, 2IRZ, 5HDU, 3UDY, 2WF2, 4B1D, 4J1C, 2ZJK, 2OF0, 4LC7, 3LPJ, 4FSE, 4EWO, 5I3X, 5QCZ, 4H3F, 5IE1, 3DM6, 4FCO, 4WY1, 4FRK, 3UDJ, 4WY6, 7F1D, 5EZX, 4JPE, 3LPK, 3UDH, 3BUH, 4I12, 2XFJ, 3IGB, 4H1E, 5QCU, 4J1E, 6EQM, 3VF3, 5QDA, 4ACU, 4WTU, 3UFL, 2OHP, 6JT3, 3S2O, 4L7G, 5QCR, 1SGZ, 2P8H, 4I0D, 2WF3, 4TRW, 4B1E, 4R91, 5HDX, 2B8V, 2ZJL, 5HDZ, 5KQF, 5QD6, 2F3E, 3VEU, 4DUS, 6BFW, 4FGX, 3VV8, 2QMD, 4BEK, 3TPP, 5QCY, 1XS7, 3I25, 5TOL, 3CIB, 1UJK
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Pharos - Targets
ZINC - Predictions - Purchasable
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P05067 APP  20 0.865 11
 UniProt:Q9UJY5 GGA1  2 0.668 4
 UniProt:P49768 PSEN1  6 0.639 6
 UniProt:P10997 IAPP  2 0.558 2
 UniProt:Q9Y287 ITM2B  1 0.556 4
 UniProt:Q9NZ52 GGA3  3 0.544 2
 UniProt:Q9UJY4 GGA2  2 0.544 2
 UniProt:Q8BNX1  1 0.524 2
 UniProt:Q03721 KCNC4  1 0.524 3
 UniProt:Q9UNH7 SNX6      0.499 2
 UniProt:O14672 ADAM10  6 0.454 3
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