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BACE1 translocates from ER lumen to Golgi apparatus

Stable Identifier
R-HSA-5693071
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Beta secretase 1 (BACE1) is acetylated on 7 lysine residues inthe ER lumen (7K-BACE1). This protects the nascent protein from degradation in the ER Golgi intermediate compartment (ERGIC) and allows it to reach the Golgi apparatus (Kandalepas & Vassar 2014). The mechanism of this translocation is unknown.

Literature References
PubMed ID Title Journal Year
24893886 The normal and pathologic roles of the Alzheimer's ?-secretase, BACE1 Curr Alzheimer Res 2014
Participants
Participant Of