FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)

Stable Identifier
R-HSA-5693081
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Golgi-associated vesicle lumen, Golgi membrane
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FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)
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FURIN is the most likely endopeptidase that cleaves the BACE propeptide domain (BACE1(22-45)) to form the mature enzyme (7K-BACE1(46-501). Although the pro-enzyme possesses proteolytic activity, this activity is approximately doubled following removal of the prodomain (Bennett et al. 2000).

Literature References
PubMed ID Title Journal Year
10956649 A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

Bennett, BD, Denis, P, Haniu, M, Teplow, DB, Kahn, S, Louis, JC, Citron, M, Vassar, R

J. Biol. Chem. 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of FURIN [Golgi membrane]
Physical Entity
FURIN [Golgi membrane]
Activity
endopeptidase activity (0004175)
Authored
Jassal, B  (2015-05-13)
Reviewed
D'Eustachio, P  (2015-06-26)
Perry, G  (2015-11-09)
Created
Jassal, B  (2015-05-13)