FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)

Stable Identifier
R-HSA-5693081
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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FURIN is the most likely endopeptidase that cleaves the BACE propeptide domain (BACE1(22-45)) to form the mature enzyme (7K-BACE1(46-501). Although the pro-enzyme possesses proteolytic activity, this activity is approximately doubled following removal of the prodomain (Bennett et al. 2000).

Literature References
PubMed ID Title Journal Year
10956649 A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

Bennett, BD, Denis, P, Haniu, M, Teplow, DB, Kahn, S, Louis, JC, Citron, M, Vassar, R

J. Biol. Chem. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of FURIN [Golgi membrane]
Physical Entity
Activity
Authored
Reviewed
Created