Reactome: A Curated Pathway Database

FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)

Stable Identifier
R-HSA-5693081
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

FURIN is the most likely endopeptidase that cleaves the BACE propeptide domain (BACE1(22-45)) to form the mature enzyme (7K-BACE1(46-501). Although the pro-enzyme possesses proteolytic activity, this activity is approximately doubled following removal of the prodomain (Bennett et al. 2000).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endopeptidase activity of FURIN [Golgi membrane] FURIN [Golgi membrane] endopeptidase activity (0004175)