Unknown deacetylase deacetylates 7K-BACE1(46-501)

Stable Identifier
R-HSA-5693092
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Golgi-associated vesicle lumen
Locations in the PathwayBrowser
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Summation

Mature beta secretase 1, acetylated on 7 lysine residues (7K-BACE1(46-501), is deacetylated by an unknown deacetylase in the Golgi apparatus (Kandalepas & Vassar 2014).

Literature References
PubMed ID Title Journal Year
24893886 The normal and pathologic roles of the Alzheimer's ?-secretase, BACE1

Kandalepas, PC, Vassar, R

Curr Alzheimer Res 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein deacetylase activity of BACE1 deacetylase [Golgi-associated vesicle lumen]
Physical Entity
BACE1 deacetylase [Golgi-associated vesicle lumen]
Activity
protein deacetylase activity (0033558)
Authored
Jassal, B  (2015-05-13)
Reviewed
D'Eustachio, P  (2015-06-26)
Perry, G  (2015-11-09)