Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
7K-BACE1(46-501) [Golgi-associated vesicle lumen]
Stable Identifier
R-HSA-5693106
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi-associated vesicle lumen
Synonyms
Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9UJY5 GGA1
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)
7K-BACE1(46-501) [Golgi-associated vesicle lumen] (Homo sapiens)
Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)
7K-BACE1(46-501) [Golgi-associated vesicle lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56817 BACE1
Gene Names
BACE1, BACE, KIAA1149
Chain
signal peptide:1-21, propeptide:22-45, chain:46-501
Reference Genes
BioGPS Gene:23621 BACE1
COSMIC (genes):BACE1 BACE1
CTD Gene:23621 BACE1
dbSNP Gene:23621 BACE1
ENSEMBL:ENSG00000186318 BACE1
ENSEMBL_homo_sapiens_GENE:ENSG00000186318.18 BACE1
HGNC:933 BACE1
KEGG Gene (Homo sapiens):23621 BACE1
Monarch:23621 BACE1
NCBI Gene:23621 BACE1
OMIM:604252 BACE1
UCSC:P56817 BACE1
Reference Transcript
RefSeq:NM_138973.3 BACE1
RefSeq:NM_012104.4 BACE1
RefSeq:NM_138972.3 BACE1
RefSeq:NM_001207049.1 BACE1
RefSeq:NM_138971.3 BACE1
Other Identifiers
11716390_a_at
11716391_a_at
11749940_a_at
11753657_a_at
11753658_x_at
11754653_a_at
16744822
217904_PM_s_at
217904_s_at
222462_PM_s_at
222462_s_at
222463_PM_s_at
222463_s_at
224335_PM_s_at
224335_s_at
23621
3393256
3393258
3393259
3393260
3393261
3393262
3393263
3393264
3393265
3393267
3393268
3393270
3393273
3393276
3393277
3393279
3393280
3393281
3393282
3393284
3393295
3393296
3393297
3393298
44849_at
45790_at
7951910
A_33_P3240936
A_33_P3240941
GE58458
GO:0001540
GO:0003824
GO:0004175
GO:0004190
GO:0005515
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005771
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005802
GO:0005886
GO:0006508
GO:0006509
GO:0008021
GO:0008233
GO:0008798
GO:0009986
GO:0010008
GO:0010288
GO:0012501
GO:0016020
GO:0016485
GO:0016787
GO:0019899
GO:0023052
GO:0030424
GO:0030425
GO:0030659
GO:0031410
GO:0034205
GO:0042987
GO:0042995
GO:0043025
GO:0043226
GO:0043525
GO:0045121
GO:0050435
GO:0050804
GO:0050877
GO:0050966
GO:0051604
GO:0055037
GO:0060134
GO:0070931
GO:0071280
GO:0071287
GO:0098686
GO:0098793
GO:0099171
GO:0140096
GO:0140448
GO:1904646
GO:1990000
HMNXSV003025985
HMNXSV003046053
Hs.49349.0.S3_3p_a_at
ILMN_1797804
ILMN_2320349
PH_hs_0003439
TC11002335.hg
TC11003367.hg
TC11003368.hg
g13568406_3p_s_at
g6118538_3p_a_at
g6912265_3p_a_at
p2517
Participates
as an output of
FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)
as an input of
Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)
Other forms of this molecule
BACE1 [endoplasmic reticulum lumen]
7K-BACE1 [endoplasmic reticulum lumen]
BACE1(22-45) [Golgi-associated vesicle lumen]
7K-BACE1 [Golgi-associated vesicle lumen]
BACE1(46-501) [Golgi-associated vesicle lumen]
BACE1(46-501) [plasma membrane]
BACE1 [endosome membrane]
Modified Residues
Name
N6-acetyl-L-lysine at 126
Coordinate
126
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 275
Coordinate
275
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 279
Coordinate
279
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 285
Coordinate
285
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 299
Coordinate
299
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 300
Coordinate
300
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 307
Coordinate
307
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
RefSeq
NP_620427.1
,
NP_620429.1
,
NP_001193978.1
,
NP_620428.1
,
NP_036236.1
ZINC - World Drugs
BACE1_HUMAN
Guide to Pharmacology - Targets
2330
OpenTargets
ENSG00000186318
ZINC - FDA approved
BACE1_HUMAN
ZINC - Substances
BACE1_HUMAN
ZINC - Biogenic
BACE1_HUMAN
ZINC target
P56817
PRO
P56817
PDB
4LXA
,
6WNY
,
4J17
,
3SKG
,
4BEK
,
3L5F
,
3RU1
,
7D36
,
5QDC
,
1XS7
,
2FDP
,
2QU3
,
4B00
,
4I0J
,
4WY1
,
3S2O
,
3INF
,
3OHH
,
1YM4
,
2Q11
,
2VNN
,
5QD8
,
3UDH
,
4PZW
,
5EZZ
,
7F1D
,
6NV7
,
6DHC
,
1TQF
,
2VJ6
,
4ACU
,
2VA7
,
5MXD
,
6UWP
,
4FS4
,
6NW3
,
4JPC
,
4J0Z
,
4GMI
,
6JSN
,
4B78
,
3R1G
,
5HDZ
,
3UQP
,
5CLM
,
4J1E
,
5QDA
,
2QMD
,
2VJ9
,
4LXM
,
4I10
,
5QCY
,
2ZJJ
,
5QD7
,
3U6A
,
3MSJ
,
3UDR
,
2P4J
,
4H3J
,
7DCZ
,
4IVT
,
5T1W
,
4R5N
,
4FGX
,
5QCW
,
5QD5
,
2WF0
,
4DH6
,
2NTR
,
2VA5
,
4DPF
,
5ENK
,
5QCT
,
3VF3
,
4AZY
,
4X2L
,
1M4H
,
4ZPE
,
3UDM
,
1UJK
,
6BFX
,
4TRZ
,
5I3X
,
5YGY
,
4H3G
,
6JSF
,
3LPJ
,
3OOZ
,
4R95
,
2IRZ
,
3EXO
,
2XFK
,
4XKX
,
4RRN
,
2OHN
,
4J1I
,
5QCV
,
6BFD
,
4KE0
,
3FKT
,
2OHQ
,
3UDP
,
2VIY
,
3HW1
,
4YBI
,
4K9H
,
4FRI
,
5MCQ
,
2ZHT
,
5HDV
,
3L5C
,
4JOO
,
4ZPG
,
4B72
,
4J0V
,
3IND
,
6DMI
,
1W50
,
6UWV
,
6JT3
,
4D88
,
5V0N
,
5F01
,
3RSX
,
4DV9
,
3INH
,
2PH6
,
5QD3
,
4EWO
,
4I1C
,
2QP8
,
4XXS
,
5HE7
,
3WB5
,
5QCR
,
3DV1
,
4LC7
,
2VKM
,
2VIE
,
3LNK
,
5HD0
,
3UQW
,
6UVP
,
5KR8
,
2G94
,
2ZJH
,
2HIZ
,
3S7L
,
7B1Q
,
4L7J
,
3TPP
,
4I0H
,
6C2I
,
4RCF
,
4TRW
,
3RTM
,
3N4L
,
4D8C
,
4B1C
,
4J1F
,
2ZE1
,
5MBW
,
3CKR
,
3BUG
,
2F3F
,
2QZK
,
3L59
,
6EJ2
,
2WF3
,
4DJV
,
7MYI
,
7N66
,
3IN4
,
2XFI
,
3CID
,
5QDD
,
5HU0
,
5QCO
,
4DJX
,
3H0B
,
3L5D
,
2VJ7
,
6NV9
,
3TPJ
,
3UDJ
,
2ZHR
,
4B05
,
5QCP
,
4I0D
,
4D83
,
4B1E
,
3IXJ
,
4I0F
,
4RCD
,
3UQR
,
7D5A
,
3L38
,
5QDB
,
2OHT
,
5I3V
,
3RVI
,
5QD1
,
4H1E
,
2Q15
,
4FM7
,
3K5F
,
4ZSQ
,
2ZJM
,
2OHL
,
4BFD
,
5HE4
,
3MSK
,
2P8H
,
4L7G
,
2OAH
,
4KE1
,
2OHR
,
4FRS
,
3QBH
,
5QD6
,
4PZX
,
7D2V
,
3IVH
,
4LXK
,
3VV6
,
4DPI
,
3CIB
,
6FGY
,
3RTN
,
3VEU
,
4ZSM
,
4FRJ
,
3LPK
,
4J0P
,
3KYR
,
3UDY
,
2HM1
,
3ZMG
,
4R8Y
,
3VG1
,
2VIZ
,
3OHF
,
2QU2
,
4WY6
,
5I3Y
,
6BFE
,
3VV8
,
4I11
,
4ACX
,
2ZHU
,
2WF1
,
3SKF
,
6E3Z
,
4J1C
,
3KN0
,
5TOL
,
3L5E
,
4JPE
,
3KMX
,
2QMF
,
3R2F
,
3INE
,
4FSE
,
5ENM
,
1XN2
,
3BRA
,
4H3I
,
3K5C
,
4IVS
,
4X7I
,
5HDX
,
5QD9
,
2ZJK
,
4J0Y
,
5QCZ
,
2VNM
,
5QCX
,
4RRO
,
4D89
,
4ZPF
,
4HZT
,
5QD4
,
2QK5
,
1W51
,
3BUH
,
5EZX
,
2QZL
,
6EJ3
,
4H3F
,
2PH8
,
5I3W
,
2OHP
,
4J1K
,
3RTH
,
2VA6
,
4R92
,
3UDQ
,
3DM6
,
4K8S
,
2ZJI
,
1PY1
,
7B1E
,
6JSG
,
1YM2
,
6PZ4
,
2VIJ
,
5UYU
,
1FKN
,
4J0T
,
3IGB
,
6UVV
,
2WF4
,
3L5B
,
3WB4
,
5HDU
,
4DI2
,
2B8L
,
4JP9
,
3LPI
,
6JT4
,
2OF0
,
5T1U
,
4R91
,
2IS0
,
4I0Z
,
4B77
,
4I12
,
4D85
,
2WJO
,
5HU1
,
2XFJ
,
2IQG
,
3DV5
,
3RSV
,
3KMY
,
3HVG
,
1XN3
,
6JSE
,
6EQM
,
2OHM
,
4J1H
,
4WTU
,
3NSH
,
5QCS
,
2OHU
,
3UQX
,
4FCO
,
2WF2
,
6BFW
,
5YGX
,
4RRS
,
3L58
,
3TPR
,
5IE1
,
3IXK
,
5MCO
,
3UDN
,
2ZJN
,
2ZHS
,
4RCE
,
4I0I
,
5QCU
,
3K5G
,
5QD2
,
4ZSR
,
2F3E
,
4TRY
,
4B70
,
2ZDZ
,
4EXG
,
7MYR
,
3CKP
,
3BUF
,
3L3A
,
4R93
,
4GID
,
3S7M
,
4DUS
,
2B8V
,
3PI5
,
3VV7
,
4B0Q
,
2P83
,
2OHK
,
4ZSP
,
7D2X
,
2OHS
,
3IVI
,
3CIC
,
3IN3
,
2QMG
,
3ZOV
,
4HA5
,
4FRK
,
5F00
,
4B1D
,
4DJU
,
5QCQ
,
3LHG
,
3UQU
,
4I0E
,
5DQC
,
7B1P
,
3QI1
,
5HE5
,
6OD6
,
2ZHV
,
5HTZ
,
4DJW
,
4I0G
,
1SGZ
,
2WEZ
,
3I25
,
5KQF
,
3TPL
,
4DJY
,
3UDK
,
2ZJL
,
4DVF
,
3MSL
,
4FM8
,
6UVY
,
4FSL
,
3DUY
,
1UJJ
,
3K5D
,
4N00
,
3UFL
,
4L7H
,
5QD0
,
7MYU
ZINC - Investigational
BACE1_HUMAN
ZINC - Metabolites
BACE1_HUMAN
HPA
ENSG00000186318-BACE1
GeneCards
P56817
Ensembl
ENSG00000186318
,
ENSP00000422461
,
ENST00000513780
,
ENSP00000424536
,
ENSP00000318585
,
ENST00000428381
,
ENST00000510630
,
ENSP00000402228
,
ENST00000392937
,
ENSP00000475405
,
ENST00000313005
,
ENST00000445823
,
ENSP00000403685
Pharos - Targets
P56817
ZINC - Predictions - Purchasable
BACE1_HUMAN
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.865
11
UniProt:Q9UJY5 GGA1
2
GGA1 [early endosome membrane]
(R-HSA-8854136)
GGA1 [endosome membrane]
(R-HSA-5692930)
0.668
4
UniProt:P49768 PSEN1
6
PSEN1(1-467) [plasma membrane]
(R-HSA-201606)
PSEN1(299-467) [azurophil granule membrane]
(R-HSA-6799234)
PSEN1(1-467) [azurophil granule membrane]
(R-HSA-6799235)
PSEN1(1-298) [azurophil granule membrane]
(R-HSA-6799209)
PSEN1(1-298) [plasma membrane]
(R-HSA-2534298)
PSEN1(299-467) [plasma membrane]
(R-HSA-2534245)
0.639
6
UniProt:P10997 IAPP
2
IAPP(1-89) [cytosol]
(R-HSA-186631)
IAPP(34-70) [extracellular region]
(R-HSA-420076)
0.558
2
UniProt:Q9Y287 ITM2B
1
ITM2B(244-266) [extracellular region]
(R-HSA-976878)
0.556
4
UniProt:Q9UJY4 GGA2
2
GGA2 [early endosome membrane]
(R-HSA-8854140)
GGA2 [endosome membrane]
(R-HSA-5692937)
0.544
2
UniProt:Q9NZ52 GGA3
3
GGA3 [endosome membrane]
(R-HSA-5692936)
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
GGA3 [early endosome membrane]
(R-HSA-8854137)
0.544
2
UniProt:Q03721 KCNC4
1
KCNC4 [plasma membrane]
(R-HSA-977458)
0.524
3
UniProt:Q8BNX1
1
Clec4g [plasma membrane]
(R-MMU-1472852)
0.524
2
UniProt:Q9UNH7 SNX6
0.499
2
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
0.454
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text