7K-BACE1(46-501) [Golgi-associated vesicle lumen]

Stable Identifier
R-HSA-5693106
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi-associated vesicle lumen
Synonyms
Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN
Icon
7K-BACE1(46-501) [Golgi-associated vesicle lumen] icon
7K-BACE1(46-501) [Golgi-associated vesicle lumen] icon
Locations in the PathwayBrowser for interactor UniProt:Q9Y287 ITM2B
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External Reference Information
External Reference
UniProt:P56817 BACE1
Gene Names
BACE1, BACE, KIAA1149
Chain
signal peptide:1-21, propeptide:22-45, chain:46-501
Reference Genes
COSMIC (genes):BACE1 BACE1
dbSNP Gene:23621 BACE1
ENSEMBL:ENSG00000186318 BACE1
Participates
as an output of
as an input of
Other forms of this molecule
BACE1 [endoplasmic reticulum lumen]
7K-BACE1 [endoplasmic reticulum lumen]
BACE1(22-45) [Golgi-associated vesicle lumen]
7K-BACE1 [Golgi-associated vesicle lumen]
BACE1(46-501) [Golgi-associated vesicle lumen]
BACE1(46-501) [plasma membrane]
BACE1 [endosome membrane]
Modified Residues
Name
N6-acetyl-L-lysine at 126
Coordinate
126
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 275
Coordinate
275
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 279
Coordinate
279
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 285
Coordinate
285
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 299
Coordinate
299
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 300
Coordinate
300
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 307
Coordinate
307
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P05067 APP  20 0.865 11
 UniProt:Q9UJY5 GGA1  2 0.668 4
 UniProt:P49768 PSEN1  6 0.639 6
 UniProt:P10997 IAPP  2 0.558 2
 UniProt:Q9Y287 ITM2B  1 0.556 4
 UniProt:Q9UJY4 GGA2  2 0.544 2
 UniProt:Q9NZ52 GGA3  3 0.544 2
 UniProt:Q03721 KCNC4  1 0.524 3
 UniProt:Q8BNX1  1 0.524 2
 UniProt:Q9UNH7 SNX6      0.499 2
 UniProt:O14672 ADAM10  6 0.454 3
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