Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BCKDK [mitochondrial matrix]
Stable Identifier
R-HSA-5693129
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial ecNumber2.7.11.4/ecNumber, BCKD_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
BCKDK phosphorylates BCKDH (Homo sapiens)
BCKDK dimer [mitochondrial matrix] (Homo sapiens)
BCKDK [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14874 BCKDK
Gene Names
BCKDK
Chain
transit peptide:1-30, chain:31-412
Reference Genes
BioGPS Gene:10295 BCKDK
COSMIC (genes):BCKDK BCKDK
CTD Gene:10295 BCKDK
dbSNP Gene:10295 BCKDK
ENSEMBL:ENSG00000103507 BCKDK
HGNC:16902 BCKDK
KEGG:hsa:10295 BCKDK
Monarch:10295 BCKDK
NCBI Gene:10295 BCKDK
OMIM:614901 BCKDK
UCSC:O14874 BCKDK
Reference Transcript
RefSeq:NM_001122957.2 BCKDK
RefSeq:NM_001271926.1 BCKDK
RefSeq:NM_005881.3 BCKDK
Other Identifiers
10295
11719705_a_at
11743293_a_at
11743294_x_at
11744767_x_at
16818165
202030_PM_at
202030_at
32828_at
3656830
3656831
3656832
3656833
3656834
3656835
3656836
3656837
3656838
3656839
3656840
3656841
3656842
3656843
3656844
3656845
3656846
3656847
3656848
3656849
3656850
3656851
3656852
3656853
3656854
7995040
A_14_P123905
A_23_P365149
A_23_P3823
GE54207
GO:0003824
GO:0004672
GO:0004674
GO:0004722
GO:0004740
GO:0005515
GO:0005524
GO:0005739
GO:0005759
GO:0006520
GO:0006629
GO:0008610
GO:0009063
GO:0009083
GO:0010906
GO:0016301
GO:0016310
GO:0016740
GO:0016772
GO:0016787
GO:0043226
GO:0045252
GO:0045763
GO:0047323
GO:0106310
GO:0140096
HMNXSV003033146
ILMN_1693394
PH_hs_0001785
TC16000370.hg
g5031608_3p_at
Participates
as a component of
BCKDK dimer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
R224P BCKDK [mitochondrial matrix]
R174Gfs1* BCKDK [mitochondrial matrix]
L389P BCKDK [mitochondrial matrix]
R156* BCKDK [mitochondrial matrix]
Inferred To
BCKDK [mitochondrial matrix]
(Bos taurus)
BCKDK [mitochondrial matrix]
(Canis familiaris)
BCKDK [mitochondrial matrix]
(Mus musculus)
BCKDK [mitochondrial matrix]
(Rattus norvegicus)
BCKDK [mitochondrial matrix]
(Sus scrofa)
bckdk [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001258855.1
,
NP_005872.2
,
NP_001116429.1
Guide to Pharmacology - Targets
1939
OpenTargets
ENSG00000103507
ENSEMBL
ENST00000394950
,
ENST00000394951
,
ENSP00000219794
,
ENSP00000287507
,
ENSP00000378405
,
ENSP00000378404
,
ENST00000287507
,
ENST00000219794
HPA
ENSG00000103507-BCKDK
PRO
O14874
Pharos - Targets
O14874
Orphanet
BCKDK
GlyGen
O14874
PDB
8F5J
,
8F5S
,
8F5F
HMDB Protein
HMDBP01493
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41208 CETN2
3
CETN2 [cytosol]
(R-HSA-380298)
CETN2 [nucleoplasm]
(R-HSA-4570490)
polySUMO2,3-CETN2 [nucleoplasm]
(R-HSA-4570486)
0.643
3
UniProt:O95395 GCNT3
1
GCNT3 [Golgi membrane]
(R-HSA-914013)
0.527
4
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.508
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text