Reactome | BCKDK [mitochondrial matrix]

BCKDK [mitochondrial matrix]

Stable Identifier

R-HSA-5693129

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial ecNumber2.7.11.4/ecNumber, BCKD_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14874 BCKDK

Gene Names

BCKDK

Chain

transit peptide:1-30, chain:31-412

Reference Genes

BioGPS Gene:10295 BCKDK

COSMIC (genes):BCKDK BCKDK

CTD Gene:10295 BCKDK

dbSNP Gene:10295 BCKDK

ENSEMBL:ENSG00000103507 BCKDK

ENSEMBL_homo_sapiens_GENE:ENSG00000103507.14 BCKDK

HGNC:16902 BCKDK

KEGG Gene (Homo sapiens):10295 BCKDK

Monarch:10295 BCKDK

NCBI Gene:10295 BCKDK

OMIM:614901 BCKDK

UCSC:O14874 BCKDK

Reference Transcript

Other Identifiers

10295

11719705_a_at

11743293_a_at

11743294_x_at

11744767_x_at

16818165

202030_PM_at

202030_at

32828_at

3656830

3656833

3656834

3656835

3656836

3656837

3656838

3656840

3656842

3656844

3656845

3656846

3656847

3656848

3656849

3656850

3656851

3656852

3656853

3656854

7995040

A_14_P123905

A_23_P365149

A_23_P3823

GE54207

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004740

GO:0005515

GO:0005524

GO:0005739

GO:0005759

GO:0005947

GO:0005975

GO:0006520

GO:0009063

GO:0009083

GO:0010906

GO:0016301

GO:0016310

GO:0016740

GO:0016772

GO:0043226

GO:0045763

GO:0047323

GO:0140096

HMNXSV003033146

ILMN_1693394

PH_hs_0001785

TC16000370.hg

g5031608_3p_at

Inferred To

BCKDK [mitochondrial matrix] (Bos taurus)

BCKDK [mitochondrial matrix] (Canis familiaris)

BCKDK [mitochondrial matrix] (Mus musculus)

BCKDK [mitochondrial matrix] (Rattus norvegicus)

BCKDK [mitochondrial matrix] (Sus scrofa)

bckdk [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001116429.1, NP_001258855.1, NP_005872.2

Guide to Pharmacology - Targets

1939

OpenTargets

ENSG00000103507

GeneCards

O14874

HPA

ENSG00000103507-BCKDK

Ensembl

ENST00000394951, ENSP00000378404, ENSP00000378405, ENSG00000103507, ENST00000219794, ENSP00000219794, ENSP00000287507, ENST00000394950, ENST00000287507

PRO

O14874

Pharos - Targets

O14874

Orphanet

21447

HMDB Protein

HMDBP01493

PDB

8F5S, 8F5J, 8F5F

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25631 YCU1			0.556	3
UniProt:P02549 SPTA1	1	SPTA1 [cytosol] (R-HSA-391563)	0.556	3
UniProt:P0DTD1-PRO_0000449629 REP			0.527	2
UniProt:O15182 CETN3			0.527	2
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.527	2
UniProt:Q9WMX2-PRO_0000037548			0.508	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.508	2

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