CECRI deaminates Ade-Rib to Ino

Stable Identifier
R-HSA-5693346
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Adenosine deaminase (CECR1, ADA2) degrades extracellular adenosine (Ade-Rib), a signaling molecule that controls a variety of cellular responses (Zavialov & Engstrom 2005). Extracellular adenosine can bind and activate four adenosine receptors (ADRs), triggering multiple intracellular processes leading to either cell activation or in suppression of cell function and cell death. ADA2 (and ADA1) decrease the local concentration of adenosine by catalysing the deamination of adenosine to inosine (Ino). ADA2 is dimeric, binding one Zn2+ ion per subunit (Zavialov et al. 2010).

Literature References
PubMed ID Title Journal Year
20147294 Structural basis for the growth factor activity of human adenosine deaminase ADA2

Zavialov, AV, Yu, X, Spillmann, D, Lauvau, G, Zavialov, AV

J. Biol. Chem. 2010
15926889 Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Zavialov, AV, Engström, A

Biochem. J. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
adenosine deaminase activity of CECR1:Zn2+ dimer [extracellular region]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created