Phosphorylation of BRCA1-A complex at multiple sites by ATM

Stable Identifier
R-HSA-5693551
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1524 and S1547 (Cortez et al. 1999, Gatei et al. 2000). At least a fraction of these sites and some additional BRCA1 SQ/TQ sites can also be phosphorylated by ATR (Tibbetts et al. 2000). ATM also phosphorylates BARD1, the heterodimerization partner of BRCA1, at threonine residues T714 and T734 (Kim et al. 2006).

Literature References
PubMed ID Title Journal Year
11114888 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, RS, Cortez, D, Brumbaugh, KM, Scully, R, Livingston, D, Elledge, SJ, Abraham, RT

Genes Dev. 2000
16651405 DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex

Kim, HS, Li, H, Cevher, M, Parmelee, A, Fonseca, D, Kleiman, FE, Lee, SB

Cancer Res. 2006
10866324 Role for ATM in DNA damage-induced phosphorylation of BRCA1

Gatei, M, Scott, SP, Filippovitch, I, Soronika, N, Lavin, MF, Weber, B, Khanna, KK

Cancer Res. 2000
10550055 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

Cortez, D, Wang, Y, Qin, J, Elledge, SJ

Science 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created