DNA-PKcs autophosphorylates

Stable Identifier
R-HSA-5693575
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Autophosphorylation of DNA-PKcs (PRKDC) is required for NHEJ in vivo, especially for endonucleolytic processing of DNA double strand break ends, which makes them suitable for ligation (Chan et al, 2002; Ding et al, 2003). In vivo, PRKDC autophosphorylates at threonine residues T2609, T2638 and T2647, and serine residue S2612 (Douglas et al. 2002).

Literature References
PubMed ID Title Journal Year
12231622 Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

Chan, DW, Chen, BP, Prithivirajsingh, S, Kurimasa, A, Story, MD, Qin, J, Chen, DJ

Genes Dev 2002
12186630 Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

Douglas, P, Sapkota, GP, Morrice, N, Yu, Y, Goodarzi, AA, Merkle, D, Meek, K, Alessi, DR, Lees-Miller, SP

Biochem J 2002
12897153 Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

Ding, Q, Reddy, YV, Wang, W, Woods, T, Douglas, P, Ramsden, DA, Lees-Miller, SP, Meek, K

Mol Cell Biol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created