D-loop dissociation and strand annealing

Stable Identifier
R-HSA-5693589
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Following repair synthesis, the extended D-loop strands may disassociate from their sister chromatid complements and reanneal with their original complementary strands. A DNA helicase RTEL1 disrupts preformed D-loops and promotes synthesis-dependent strand annealing, yielding non-crossover products and preventing excessive recombination between mitotic sister chromatids (Barber et al. 2008, Uringa et al. 2012).

Literature References
PubMed ID Title Journal Year
22593209 RTEL1 contributes to DNA replication and repair and telomere maintenance

Uringa, EJ, Lisaingo, K, Pickett, HA, Brind'Amour, J, Rohde, JH, Zelensky, A, Essers, J, Lansdorp, PM

Mol. Biol. Cell 2012
18957201 RTEL1 maintains genomic stability by suppressing homologous recombination

Barber, LJ, Youds, JL, Ward, JD, McIlwraith, MJ, O'Neil, NJ, Petalcorin, MI, Martin, JS, Collis, SJ, Cantor, SB, Auclair, M, Tissenbaum, H, West, SC, Rose, AM, Boulton, SJ

Cell 2008
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
ATP-dependent DNA helicase activity of RTEL1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed