ATM phosphorylates NBN

Stable Identifier
R-HSA-5693598
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NSB1 (NBN) is a component of the MRN (MRE11:RAD50:NBN) complex which acts early in homologous recombination repair (HRR) during recognition and resection of double-strand breaks (DSBs). ATM-mediated phosphorylation of NBN at serine residue S343 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR (Lim et al. 2000, Gatei et al. 2000, Lee and Paull 2004). The phosphorylation of NBN by ATM may be enhanced by the presence of BRCA1 (Foray et al. 2003).

Literature References
PubMed ID Title Journal Year
10766245 ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, DS, Kim, ST, Xu, B, Maser, RS, Lin, J, Petrini, JH, Kastan, MB

Nature 2000
10802669 ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M, Young, D, Cerosaletti, KM, Desai-Mehta, A, Spring, K, Kozlov, S, Lavin, MF, Gatti, RA, Concannon, P, Khanna, K

Nat. Genet. 2000
15064416 Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

Lee, JH, Paull, TT

Science 2004
12773400 A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.

Foray, N, Marot, D, Gabriel, A, Randrianarison, V, Perricaudet, M, Ashworth, A, Jeggo, P

EMBO J 2003
Participants
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created