DNA Double Strand Break Response

Stable Identifier
R-HSA-5693606
Type
Pathway
Species
Homo sapiens
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Summation

DNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signaling, as well as proteins directly involved in the repair of DNA DSBs. For a recent review, please refer to Ciccia and Elledge, 2010.

Literature References
PubMed ID Title Journal Year
20965415 The DNA damage response: making it safe to play with knives

Ciccia, A, Elledge, SJ

Mol. Cell 2010
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Events
Participant Of
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Orthologous Events
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