DNA Double Strand Break Response

Stable Identifier
R-HSA-5693606
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Expand all
Summation

DNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signaling, as well as proteins directly involved in the repair of DNA DSBs. For a recent review, please refer to Ciccia and Elledge, 2010.

Literature References
PubMed ID Title Journal Year
20965415 The DNA damage response: making it safe to play with knives

Ciccia, A, Elledge, SJ

Mol. Cell 2010
Participants
Events
Participant Of
hasEvent
Orthologous Events
DNA Double Strand Break Response (Arabidopsis thaliana)
DNA Double Strand Break Response (Bos taurus)
DNA Double Strand Break Response (Caenorhabditis elegans)
DNA Double Strand Break Response (Canis familiaris)
DNA Double Strand Break Response (Danio rerio)
DNA Double Strand Break Response (Dictyostelium discoideum)
DNA Double Strand Break Response (Drosophila melanogaster)
DNA Double Strand Break Response (Gallus gallus)
DNA Double Strand Break Response (Mus musculus)
DNA Double Strand Break Response (Oryza sativa)
DNA Double Strand Break Response (Plasmodium falciparum)
DNA Double Strand Break Response (Rattus norvegicus)
DNA Double Strand Break Response (Saccharomyces cerevisiae)
DNA Double Strand Break Response (Schizosaccharomyces pombe)
DNA Double Strand Break Response (Sus scrofa)
DNA Double Strand Break Response (Taeniopygia guttata)
DNA Double Strand Break Response (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)