Reactome: A Curated Pathway Database

DNA Double Strand Break Response

Stable Identifier
R-HSA-5693606
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

DNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signaling, as well as proteins directly involved in the repair of DNA DSBs. For a recent review, please refer to Ciccia and Elledge, 2010.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events