DNA Double Strand Break Response

Summation

DNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signaling, as well as proteins directly involved in the repair of DNA DSBs. For a recent review, please refer to Ciccia and Elledge, 2010.

Participants

Events

• Sensing of DNA Double Strand Breaks (Homo sapiens)
• Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)

Participant Of

hasEvent

• DNA Double-Strand Break Repair

Orthologous Events

DNA Double Strand Break Response (Arabidopsis thaliana)

DNA Double Strand Break Response (Bos taurus)

DNA Double Strand Break Response (Caenorhabditis elegans)

DNA Double Strand Break Response (Canis familiaris)

DNA Double Strand Break Response (Danio rerio)

DNA Double Strand Break Response (Dictyostelium discoideum)

DNA Double Strand Break Response (Drosophila melanogaster)

DNA Double Strand Break Response (Gallus gallus)

DNA Double Strand Break Response (Mus musculus)

DNA Double Strand Break Response (Oryza sativa)

DNA Double Strand Break Response (Plasmodium falciparum)

DNA Double Strand Break Response (Rattus norvegicus)

DNA Double Strand Break Response (Saccharomyces cerevisiae)

DNA Double Strand Break Response (Schizosaccharomyces pombe)

DNA Double Strand Break Response (Sus scrofa)

DNA Double Strand Break Response (Taeniopygia guttata)

DNA Double Strand Break Response (Xenopus tropicalis)

Authored

Orlic-Milacic, M  (2015-05-12)

Reviewed

Borowiec, JA  (2015-06-12)

Created

Orlic-Milacic, M  (2015-05-16)