ATM phosphorylates TP53 at S15

Stable Identifier
R-HSA-5693609
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In response to DNA double strand breaks, serine at position 15 of the TP53 (p53) tumor suppressor protein is rapidly phosphorylated by the ATM kinase. This serves to stabilize the p53 protein. A rise in the levels of the p53 protein induces the expression of p21 cyclin-dependent kinase inhibitor. This prevents the normal progression from G1 to S phase, thus providing a check on replication of damaged DNA (Banin et al. 1998, Canman et al. 1998, Khanna et al. 1998).

Literature References
PubMed ID Title Journal Year
9733515 Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Canman, CE, Lim, DS, Taya, Y, Tamai, K, Sakaguchi, K, Appella, E, Kastan, MB, Siliciano, JD

Science 1998
9843217 ATM associates with and phosphorylates p53: mapping the region of interaction.

Khanna, KK, Keating, KE, Kozlov, S, Scott, S, Gatei, M, Hobson, K, Taya, Y, Gabrielli, B, Chan, D, Lees-Miller, SP, Lavin, MF

Nat Genet 1998
9733514 Enhanced phosphorylation of p53 by ATM in response to DNA damage.

Banin, S, Moyal, L, Shieh, S, Taya, Y, Anderson, CW, Chessa, L, Smorodinsky, NI, Prives, C, Reiss, Y, Shiloh, Y, Ziv, Y

Science 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created