Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis

Stable Identifier
R-HSA-5693615
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DNA-PKcs (PRKDC) is recruited to the Ku70:Ku80:DNA double strand break ends complex (XRCC5:XRCC6:DNA DSBs) (Gottlieb and Jackson, 1993), causing Ku to translocate inwards (away from the break) approximately 10 bp (Yoo and Dynan, 1999). This forms the DNA-PK complex (DNA-PKcs plus Ku70/Ku80) at each end of the DSB. Two DNA-PK complexes, one on either side of the DSB, interact to bring the DNA ends together.

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Orthologous Events
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