D-loop formation mediated by PALB2, BRCA2 and RAD51

Stable Identifier
R-HSA-5693620
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Strand exchange/Branch migration mediated by PALB2, BRCA2 and RAD51
Locations in the PathwayBrowser
Summation

A D-loop structure is formed when complementary duplex DNA (sister chromatid arm) is progressively invaded by the RAD51 nucleoprotein filament, with base pairing of the invading ssDNA and the complementary sister chromatid DNA strand (Sung et al. 2003). PALB2 and RAD51AP1 synergistically stimulate RAD51 recombinase activity, thus enhancing RAD51-mediated strand exchange (branch migration) and promoting the formation of D-loop structures (synaptic complex assembly). PALB2 simultaneously interacts with RAD51, BRCA2 and RAD51AP1 (Modesti et al. 2007, Wiese et al. 2007, Buisson et al. 2010, Dray et al. 2010). The direct BRCA1 interaction with PALB2 helps to fine-tune the localization of BRCA2 and RAD51 at DNA double strand breaks (DSBs) (Zhang et al. 2009, Sy et al. 2009).

Participants
Participant Of
Orthologous Events