DUOX1,2 reduce O2 to H2O2

Stable Identifier
R-HSA-5693681
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Dual oxidases 1 and 2 (DUOX1, 2) mediates the generation of hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase for thyroid hormone formation and lactoperoxidase (Edens et al. 2001, Ameziane-El-Hassani et al. 2005).

Literature References
PubMed ID Title Journal Year
15972824 Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity

Ameziane-El-Hassani, R, Morand, S, Boucher, JL, Frapart, YM, Apostolou, D, Agnandji, D, Gnidehou, S, Ohayon, R, Noël-Hudson, MS, Francon, J, Lalaoui, K, Virion, A, Dupuy, C

J. Biol. Chem. 2005
11514595 Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox

Edens, WA, Sharling, L, Cheng, G, Shapira, R, Kinkade, JM, Lee, T, Edens, HA, Tang, X, Sullards, C, Flaherty, DB, Benian, GM, Lambeth, JD

J. Cell Biol. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD(P)H oxidase (H(2)O(2)-forming activity of DUOX1,2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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