ESD dimer hydrolyses S-FGSH to GSH

Stable Identifier
R-HSA-5693724
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

S-formylglutathione hydrolase (ESD, esterase D) is a homodimeric enzyme in the ER lumen of red blood cells that can hydrolyse S-formylglutathione (S-FGSH) to glutathione (GSH) and formate (Hopkinson et al. 1973, Eiberg & Mohr 1986). It is also able to hydrolyse 4-methylumbelliferyl acetate (not shown here).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
S-formylglutathione hydrolase activity of ESD dimer [endoplasmic reticulum lumen]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea