ESD dimer hydrolyses S-FGSH to GSH

Stable Identifier
R-HSA-5693724
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

S-formylglutathione hydrolase (ESD, esterase D) is a homodimeric enzyme in the ER lumen of red blood cells that can hydrolyse S-formylglutathione (S-FGSH) to glutathione (GSH) and formate (Hopkinson et al. 1973, Eiberg & Mohr 1986). It is also able to hydrolyse 4-methylumbelliferyl acetate (not shown here).

Literature References
PubMed ID Title Journal Year
3770744 Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells

Eiberg, H, Mohr, J

Hum. Genet. 1986
4768551 Esterase D: a new human polymorphism

Hopkinson, DA, Mestriner, MA, Cortner, J, Harris, H

Ann. Hum. Genet. 1973
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
S-formylglutathione hydrolase activity of ESD dimer [endoplasmic reticulum lumen]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed