Fatty acid amides are a class of lipid transmitters that include the endogenous cannabinoid anandamide (AEA) and the sleep-inducing chemical oleamide. The magnitude and duration of their signalling are controlled by enzymatic hydrolysis mediated by fatty-acid amide hydrolases 1 and 2 (FAAH, H2). Hydrolysis of AEA is described here (Wei et al. 2006). FAAH is localised to the ER membrane whereas FAAH2 is localised to lipid droplets (Kaczocha et al. 2010).
Cravatt, BF, Wei, BQ, Lander, ES, McKinney, MK, Mikkelsen, TS
Deutsch, DG, Glaser, ST, Brown, DA, Chae, J, Kaczocha, M
fatty acid amide hydrolase activity of FAAH [endoplasmic reticulum membrane]
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