FA2H hydroxylates CERA

Stable Identifier
R-HSA-5693761
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In mammals, 2-hydroxysphingolipids are abundant in the brain as components of the major myelin lipids galactosylceramides and sulfatides. 2-hydroxylation of sphingolipids can occur during de novo ceramide synthesis and is catalysed by fatty acid 2-hydroxylase (FA2H), an ER membrane-associated enzyme (Alderson et al. 2004, Uchida et al. 2007).

Literature References
PubMed ID Title Journal Year
15337768 The human FA2H gene encodes a fatty acid 2-hydroxylase

Alderson, NL, Rembiesa, BM, Walla, MD, Bielawska, A, Bielawski, J, Hama, H

J. Biol. Chem. 2004
17355976 Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation

Uchida, Y, Hama, H, Alderson, NL, Douangpanya, S, Wang, Y, Crumrine, DA, Elias, PM, Holleran, WM

J. Biol. Chem. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid alpha-hydroxylase activity of FA2H [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created