DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

Stable Identifier
R-HSA-5694018
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The last step in the glycine cleavage system is the reoxidation of the reduced lipoate (dihydrolipoyl group) attached to the H protein (GCSH:DHLL) catalysed by the L protein (mitochondrial dihydrolipoyl dehydrogenase, DLD) (Harris et al. 1997, Ciszak et al. 2006).

Literature References
PubMed ID Title Journal Year
16263718 How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex

Ciszak, EM, Makal, A, Hong, YS, Vettaikkorumakankauv, AK, Korotchkina, LG, Patel, MS

J. Biol. Chem. 2006
9242632 Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex.

Harris, RA, Bowker-Kinley, MM, Wu, P, Jeng, J, Popov, KM

J Biol Chem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dihydrolipoyl dehydrogenase activity of DLD dimer:2xFAD [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!