GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

Stable Identifier
R-HSA-5694071
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
GLO1 dimer:2xZn2+ trnasforms glutathione and methylglyoxal to lactoylglutathione
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Lactoylglutathione lyase (GLO1) catalyses the transformation of methylglyoxal (MGXL) and glutathione (GSH) to (R)-S-lactoylglutathione ((R)-S-LGSH), an intermediate in pyruvate metabolism. MGXL is a reactive 2-oxoaldehyde byproduct of normal metabolism that is a carcinogen and a mutagen (Ridderstrom et al. 1998). This is the first step in the glyoxalase system, a critical two-step detoxification system for MGXL.

Literature References
PubMed ID Title Journal Year
9705294 Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I

Ridderström, M, Cameron, AD, Jones, TA, Mannervik, B

J. Biol. Chem. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lactoylglutathione lyase activity of GLO1 dimer:2xZn2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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