Reactome: A Curated Pathway Database

GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

Stable Identifier
R-HSA-5694071
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
GLO1 dimer:2xZn2+ trnasforms glutathione and methylglyoxal to lactoylglutathione
Locations in the PathwayBrowser
Summation

Lactoylglutathione lyase (GLO1) catalyses the transformation of methylglyoxal (MGXL) and glutathione (GSH) to (R)-S-lactoylglutathione ((R)-S-LGSH), an intermediate in pyruvate metabolism. MGXL is a reactive 2-oxoaldehyde byproduct of normal metabolism that is a carcinogen and a mutagen (Ridderstrom et al. 1998). This is the first step in the glyoxalase system, a critical two-step detoxification system for MGXL.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
lactoylglutathione lyase activity of GLO1 dimer:2xZn2+ [cytosol] GLO1 dimer:2xZn2+ [cytosol] lactoylglutathione lyase activity (0004462)
Orthologous Events
Cross References
Rhea