Reactome | GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

Stable Identifier

R-HSA-5694071

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

GLO1 dimer:2xZn2+ trnasforms glutathione and methylglyoxal to lactoylglutathione

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GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

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Lactoylglutathione lyase (GLO1) catalyses the transformation of methylglyoxal (MGXL) and glutathione (GSH) to (R)-S-lactoylglutathione ((R)-S-LGSH), an intermediate in pyruvate metabolism. MGXL is a reactive 2-oxoaldehyde byproduct of normal metabolism that is a carcinogen and a mutagen (Ridderstrom et al. 1998). This is the first step in the glyoxalase system, a critical two-step detoxification system for MGXL.

Literature References

PubMed ID	Title	Journal	Year
9705294	Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I Ridderström, M, Cameron, AD, Jones, TA, Mannervik, B	J. Biol. Chem.	1998