Lactoylglutathione lyase (GLO1) catalyses the transformation of methylglyoxal (MGXL) and glutathione (GSH) to (R)-S-lactoylglutathione ((R)-S-LGSH), an intermediate in pyruvate metabolism. MGXL is a reactive 2-oxoaldehyde byproduct of normal metabolism that is a carcinogen and a mutagen (Ridderstrom et al. 1998). This is the first step in the glyoxalase system, a critical two-step detoxification system for MGXL.
Ridderström, M, Cameron, AD, Jones, TA, Mannervik, B
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