EPHX1 hydrates BaP4,5O to BaP4,5-DHD

Stable Identifier
R-HSA-5694077
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Microsomal epoxide hydrolase 1 (EPHX1) is involved in the metabolism of many potentially carcinogenic and/or genotoxic epoxides, such as those derived from the oxidation of polyaromatic hydrocarbons. It catalyses the hydration of arene and aliphatic epoxides to less reactive and more water-soluble dihydrodiols. An example substrate is epoxide benzo(a)pyrene 4,5-oxide (BaP4,5O), hydrated to benzo(a)pyrene 4,5-dihydrodiol (BaP4,5DHD) (Hosagrahara et al. 2004, Fretland & Omiecinski 2000).

Literature References
PubMed ID Title Journal Year
15535985 Functional analysis of human microsomal epoxide hydrolase genetic variants

Hosagrahara, VP, Rettie, AE, Hassett, C, Omiecinski, CJ

Chem. Biol. Interact. 2004
11154734 Epoxide hydrolases: biochemistry and molecular biology

Fretland, AJ, Omiecinski, CJ

Chem. Biol. Interact. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cis-stilbene-oxide hydrolase activity of EPHX1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created