XK:KEL:Zn2+ cleaves EDN3

Stable Identifier
R-HSA-5694082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The Kell blood group glycoprotein (KEL) is a zinc endopeptidase with endothelin-3-converting enzyme activity which can preferentially cleave endothelin-3 (EDN3), an endothelium-derived vasoconstrictor peptide. EDN3 is cleaved at Trp21-Ile22 to form the bioactive peptide EDN3(97-117) (Lee et al. 1999). KEL forms a heterodimer with membrane transport protein XK (Russo et al. 1998).
Literature References
PubMed ID Title Journal Year
10438732 Proteolytic processing of big endothelin-3 by the kell blood group protein

Mele, A, Russo, D, Farmar, J, Redman, C, Lee, S, Lin, M, Cao, Y

Blood 1999
9593744 Association of XK and Kell blood group proteins

Russo, D, Redman, C, Lee, S

J. Biol. Chem. 1998
Participants
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Catalyst Activity

metalloendopeptidase activity of XK:KEL:Zn2+ [plasma membrane]

Orthologous Events
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