Reactome: A Curated Pathway Database

SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine

Stable Identifier
R-HSA-5694137
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial serine hydroxymethyltransferase (SHMT2) contributes to the de novo mitochondrial thymidylate biosynthesis pathway which is essential for mitochondrial DNA (mtDNA) integrity. It is associated with the inner mitochondrial membrane and is functional as a homotetramer. SHMT2 transfers a hydroxymethyl group from 5,10-methylenetetrahydrofolate (5,10MTHF) to glycine (Gly), forming tetrahydrofolate (THF) and L-serine (L-Ser) (Anderson et al. 2011).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
glycine hydroxymethyltransferase activity of SHMT2 tetramer [mitochondrial inner membrane] SHMT2 tetramer [mitochondrial inner membrane] glycine hydroxymethyltransferase activity (0004372)
Orthologous Events