SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine

Stable Identifier
R-HSA-5694137
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial serine hydroxymethyltransferase (SHMT2) contributes to the de novo mitochondrial thymidylate biosynthesis pathway which is essential for mitochondrial DNA (mtDNA) integrity. It is associated with the inner mitochondrial membrane and is functional as a homotetramer. SHMT2 transfers a hydroxymethyl group from 5,10-methylenetetrahydrofolate (5,10MTHF) to glycine (Gly), forming tetrahydrofolate (THF) and L-serine (L-Ser) (Anderson et al. 2011).

Literature References
PubMed ID Title Journal Year
21876188 Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycine hydroxymethyltransferase activity of SHMT2 tetramer [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events