Nucleotide exchange on RAB1

Stable Identifier
R-HSA-5694409
Type
Reaction
Species
Homo sapiens
Compartment
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The TRAPPC complex acts as a guanine-nucleotide exchange factor for RAB1, activating it (Yamasaki et al, 2009; reviewed in Brunet and Sacher, 2014).

Literature References
PubMed ID Title Journal Year
24917561 In sickness and in health: the role of TRAPP and associated proteins in disease

Brunet, S, Sacher, M

Traffic 2014
19656848 mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles

Yamasaki, A, Menon, S, Yu, S, Barrowman, J, Meerloo, T, Oorschot, V, Klumperman, J, Satoh, A, Ferro-Novick, S

Mol. Biol. Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created