RAB1:GTP binds USO1 and GORASP1:GOLGA2

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R-HSA-5694418
Type
Reaction
Species
Homo sapiens
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Protein protein interactions involving activated RAB1:GTP help dock the ER-derived vesicle on the cis-Golgi membrane (reviewed in Lord et al, 2013) . Independently, RAB:GTP interacts with both the USO1 homodimer (a long coiled coil tethering factor also known as p115) and the GOLGA2 component of the GOLGA2:GORASP1 complex on the cis-Golgi membrane (Allan et al, 2000; Moyer et al, 2001; Weide et al, 2001). USO1 also contacts GOLGA2 directly (Nakamura et al, 1997; Seeman et al, 2000). t-SNARES such as STX5, GOSR1and GOSR2 also participate in this complex on the cis-ERGIC membrane (Brandon et al, 2006; Shorter et al, 2002; reviewed in Brandizzi and Barlowe, 2013).

Literature References
PubMed ID Title Journal Year
11285137 Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering

Moyer, BD, Allan, BB, Balch, WE

Traffic 2001
23698585 Organization of the ER-Golgi interface for membrane traffic control

Brandizzi, F, Barlowe, C

Nat. Rev. Mol. Cell Biol. 2013
9150144 The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner

Nakamura, N, Lowe, M, Levine, TP, Rabouille, C, Warren, G

Cell 1997
11927603 Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115

Shorter, J, Beard, MB, Seemann, J, Dirac-Svejstrup, AB, Warren, G

J. Cell Biol. 2002
23378591 The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi

Lord, C, Ferro-Novick, S, Miller, EA

Cold Spring Harb Perspect Biol 2013
16624868 On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo

Brandon, E, Szul, T, Alvarez, C, Grabski, R, Benjamin, R, Kawai, R, Sztul, E

Mol. Biol. Cell 2006
11306556 The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b

Weide, T, Bayer, M, Köster, M, Siebrasse, JP, Peters, R, Barnekow, A

EMBO Rep. 2001
10679020 The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo

Seemann, J, Jokitalo, EJ, Warren, G

Mol. Biol. Cell 2000
10903204 Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion

Allan, BB, Moyer, BD, Balch, WE

Science 2000
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