ABHD3 hydrolyses LPC(14:0) to 1AGPC

Stable Identifier
R-HSA-5694485
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phospholipase ABHD3 selectively cleaves medium-chain and oxidatively-truncated phospholipids, having much higher phospholipase activity toward C14-containing phosphatidylcholines such as lysophosphatidylcholine (LPC(14:0)) and producing 1-acylglycerophosphocholine (1AGPC) (Long et al. 2011). ABHD3 is ubiquitously expressed with highest expression in brain and small intestine (Lord et al. 2013).
Literature References
PubMed ID Title Journal Year
23328280 Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism

Thomas, G, Brown, JM, Lord, CC

Biochim. Biophys. Acta 2013
21926997 Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

Cravatt, BF, Wang, C, Cisar, JS, Milliken, D, Trauger, SA, Long, JZ, Niessen, S, Siuzdak, G

Nat. Chem. Biol. 2011
Participants
Participates
Catalyst Activity

phospholipase A1 activity of ABHD3 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!